Recovery of outer retinal laminations on optical coherence tomography after treatment of cancer associated retinopathy

Francisco J. Irizarry, Laura J. Kopplin, Sherveen S. Salek, Grazyna Adamus, Mohamed Saleh, Kristin Biggee, Phoebe Lin, James (Jim) Rosenbaum

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose To report novel optical coherence tomography findings in a case of anti-α-enolase cancer associated retinopathy. Observations An elderly female presented with bilateral decreased vision and a recent diagnosis of ovarian carcinoma. Optical coherence tomography demonstrated bilateral loss of outer retinal structures and macular edema. Serum testing found antibodies against α-enolase and 82–84 kDa proteins. Outer retinal structures showed recovery, macular edema resolved and repeat anti-retinal antibody testing became negative following cancer therapy and topical difluprednate treatment. Conclusions and importance Cancer associated retinopathy is a paraneoplastic disease that results in damage to retinal structures through an autoimmune response. The damage is generally considered to be irreversible; however, in rare cases, such as observed here, retinal structures may demonstrate recovery after treatment.

Original languageEnglish (US)
Pages (from-to)11-13
Number of pages3
JournalAmerican Journal of Ophthalmology Case Reports
Volume8
DOIs
StatePublished - Dec 1 2017

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Ocular Paraneoplastic Syndromes
Optical Coherence Tomography
Macular Edema
Phosphopyruvate Hydratase
Papilledema
Autoimmunity
Anti-Idiotypic Antibodies
Therapeutics
Carcinoma
Antibodies
Serum
Neoplasms
Proteins

Keywords

  • Cancer associated retinopathy
  • Optical coherence tomography

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Recovery of outer retinal laminations on optical coherence tomography after treatment of cancer associated retinopathy. / Irizarry, Francisco J.; Kopplin, Laura J.; Salek, Sherveen S.; Adamus, Grazyna; Saleh, Mohamed; Biggee, Kristin; Lin, Phoebe; Rosenbaum, James (Jim).

In: American Journal of Ophthalmology Case Reports, Vol. 8, 01.12.2017, p. 11-13.

Research output: Contribution to journalArticle

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