Recovery of outer retinal laminations on optical coherence tomography after treatment of cancer associated retinopathy

Francisco J. Irizarry; Laura J. Kopplin; Sherveen S. Salek; Grazyna Adamus; Mohamed Saleh; Kristin Biggee; Phoebe Lin; James T. Rosenbaum

doi:10.1016/j.ajoc.2017.08.001

Recovery of outer retinal laminations on optical coherence tomography after treatment of cancer associated retinopathy

Francisco J. Irizarry, Laura J. Kopplin, Sherveen S. Salek, Grazyna Adamus, Mohamed Saleh, Kristin Biggee, Phoebe Lin, James T. Rosenbaum

Ophthalmology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Purpose To report novel optical coherence tomography findings in a case of anti-α-enolase cancer associated retinopathy. Observations An elderly female presented with bilateral decreased vision and a recent diagnosis of ovarian carcinoma. Optical coherence tomography demonstrated bilateral loss of outer retinal structures and macular edema. Serum testing found antibodies against α-enolase and 82–84 kDa proteins. Outer retinal structures showed recovery, macular edema resolved and repeat anti-retinal antibody testing became negative following cancer therapy and topical difluprednate treatment. Conclusions and importance Cancer associated retinopathy is a paraneoplastic disease that results in damage to retinal structures through an autoimmune response. The damage is generally considered to be irreversible; however, in rare cases, such as observed here, retinal structures may demonstrate recovery after treatment.

Original language	English (US)
Pages (from-to)	11-13
Number of pages	3
Journal	American Journal of Ophthalmology Case Reports
Volume	8
DOIs	https://doi.org/10.1016/j.ajoc.2017.08.001
State	Published - Dec 1 2017

Keywords

Cancer associated retinopathy
Optical coherence tomography

ASJC Scopus subject areas

Ophthalmology

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10.1016/j.ajoc.2017.08.001

Cite this

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title = "Recovery of outer retinal laminations on optical coherence tomography after treatment of cancer associated retinopathy",

abstract = "Purpose To report novel optical coherence tomography findings in a case of anti-α-enolase cancer associated retinopathy. Observations An elderly female presented with bilateral decreased vision and a recent diagnosis of ovarian carcinoma. Optical coherence tomography demonstrated bilateral loss of outer retinal structures and macular edema. Serum testing found antibodies against α-enolase and 82–84 kDa proteins. Outer retinal structures showed recovery, macular edema resolved and repeat anti-retinal antibody testing became negative following cancer therapy and topical difluprednate treatment. Conclusions and importance Cancer associated retinopathy is a paraneoplastic disease that results in damage to retinal structures through an autoimmune response. The damage is generally considered to be irreversible; however, in rare cases, such as observed here, retinal structures may demonstrate recovery after treatment.",

keywords = "Cancer associated retinopathy, Optical coherence tomography",

author = "Irizarry, {Francisco J.} and Kopplin, {Laura J.} and Salek, {Sherveen S.} and Grazyna Adamus and Mohamed Saleh and Kristin Biggee and Phoebe Lin and Rosenbaum, {James T.}",

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doi = "10.1016/j.ajoc.2017.08.001",

language = "English (US)",

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T1 - Recovery of outer retinal laminations on optical coherence tomography after treatment of cancer associated retinopathy

AU - Irizarry, Francisco J.

AU - Kopplin, Laura J.

AU - Salek, Sherveen S.

AU - Adamus, Grazyna

AU - Saleh, Mohamed

AU - Biggee, Kristin

AU - Lin, Phoebe

AU - Rosenbaum, James T.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Purpose To report novel optical coherence tomography findings in a case of anti-α-enolase cancer associated retinopathy. Observations An elderly female presented with bilateral decreased vision and a recent diagnosis of ovarian carcinoma. Optical coherence tomography demonstrated bilateral loss of outer retinal structures and macular edema. Serum testing found antibodies against α-enolase and 82–84 kDa proteins. Outer retinal structures showed recovery, macular edema resolved and repeat anti-retinal antibody testing became negative following cancer therapy and topical difluprednate treatment. Conclusions and importance Cancer associated retinopathy is a paraneoplastic disease that results in damage to retinal structures through an autoimmune response. The damage is generally considered to be irreversible; however, in rare cases, such as observed here, retinal structures may demonstrate recovery after treatment.

AB - Purpose To report novel optical coherence tomography findings in a case of anti-α-enolase cancer associated retinopathy. Observations An elderly female presented with bilateral decreased vision and a recent diagnosis of ovarian carcinoma. Optical coherence tomography demonstrated bilateral loss of outer retinal structures and macular edema. Serum testing found antibodies against α-enolase and 82–84 kDa proteins. Outer retinal structures showed recovery, macular edema resolved and repeat anti-retinal antibody testing became negative following cancer therapy and topical difluprednate treatment. Conclusions and importance Cancer associated retinopathy is a paraneoplastic disease that results in damage to retinal structures through an autoimmune response. The damage is generally considered to be irreversible; however, in rare cases, such as observed here, retinal structures may demonstrate recovery after treatment.

KW - Cancer associated retinopathy

KW - Optical coherence tomography

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Recovery of outer retinal laminations on optical coherence tomography after treatment of cancer associated retinopathy

Abstract

Keywords

ASJC Scopus subject areas

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