TY - JOUR
T1 - Recommendations for the pharmacological management of neuropathic pain
T2 - An overview and literature update
AU - Dworkin, Robert H.
AU - O'Connor, Alec B.
AU - Audette, Joseph
AU - Baron, Ralf
AU - Gourlay, Geoffrey K.
AU - Haanpää, Maija L.
AU - Kent, Joel L.
AU - Krane, Elliot J.
AU - LeBel, Alyssa A.
AU - Levy, Robert M.
AU - Mackey, Sean C.
AU - Mayer, John
AU - Miaskowski, Christine
AU - Raja, Srinivasa N.
AU - Rice, Andrew S.C.
AU - Schmader, Kenneth E.
AU - Stacey, Brett
AU - Stanos, Steven
AU - Treede, Rolf Detlef
AU - Turk, Dennis C.
AU - Walco, Gary A.
AU - Wells, Christopher D.
N1 - Funding Information:
Support for the meeting on which this article is based and article preparation was provided by an unrestricted grant from Endo Pharmaceuticals to the University of Rochester Office of Continuing Professional Education, from which all authors received honoraria for their participation. Individual disclosures can be found on page S11.
Funding Information:
Individual Disclosures for Authors: Dr Dworkin has received in the past 12 months research support from Arcion, Montel Williams Foundation, and NeurogesX and consulting fees from Allergan, Astellas, AstraZeneca, Boehringer Ingelheim, Durect, Eisai, Endo Pharmaceuticals, Epicept, Forest, Genzyme, Johnson & Johnson, Eli Lilly, Michael J. Fox Foundation for Parkinson's Research, NeurogesX, Nuvo, Pfizer, PainReform, Philips Respironics, Sanofi Aventis, Solace, Solvay, Spinifex, UCB Pharma, US Department of Veterans Affairs, US National Institutes of Health, Wyeth, and Xenon; Dr O'Connor has no financial arrangement or affiliation with a corporate organization or a manfacturer of a product discussed in this supplement; Dr Audette has served on the speakers' bureau for Allergan, Endo Pharmaceuticals, and Johnson & Johnson; Dr Baron has received grant/research support from Pfizer Pharma, Genzyme, and Grünenthal and has served on the speakers' bureau and as a consultant for Pfizer Pharma, Genzyme, Grünenthal, Mundipharma, Allergan, Sanofi Pasteur, Astellas, Eisai, Medtronic, USB, and Eli Lilly; Dr. Gourlay has no financial arrangement or affiliation with a corporate organization or a manfacturer of a product discussed in this supplement; Dr Haanpää has served as consultant for Boehringer Ingelheim, GlaxoSmithKline, Eli Lilly, Medtronic, MSD, Mundipharma, Orion, Pfizer, and Sanofi Pasteur and is a permanent assessor of EMEA; Dr Kent has received grant/research support from GlaxoSmithKline and has served on the speakers' bureau for Medtronic; Dr Krane has no financial arrangement or affiliation with a corporate organization or a manfacturer of a product discussed in this supplement; Dr LeBel has no financial arrangement or affiliation with a corporate organization or a manfacturer of a product discussed in this supplement; Dr Levy has received grant/research support from St. Jude Medical Neuromodulation, has served as a consultant for Bioness, Codman, Medtronic, St Jude Medical Neuromodulation, and Stryker; Dr Mackey has no financial arrangement or affiliation with a corporate organization or a manfacturer of a product discussed in this supplement; Dr Mayer has received grant/research support from Johnson & Johnson and is on the Clinical Advisory Board for Palladian Health; Dr Miaskowski has no financial arrangement or affiliation with a corporate organization or a manfacturer of a product discussed in this supplement; Dr Raja has received grant/research support from Allergan and Medtronic and served as a consultant for Allergan, Alpharma (King), Schering-Plough, and Solvay; Dr Rice has received grant/research support from Pfizer and Spinifex and has served as a consultant for Pfizer, Allergen, Astellas, Daiichi Sankyo, GlaxoSmithKline, NeurogesX, Spinifex, and Eisia; Dr Schmader has received grant/research support from Merck and Wyeth and has served as a consultant for Merck and GlaxoSmithKline; Dr Stacey has received grant/research support from AstraZeneca and has served as a consultant for GlaxoSmithKline, Boehringer Ingelheim, Boston Scientific, Eli Lilly, Niktar, QRX Pharma, Pfizer, AstraZeneca, and Xenon; Dr Stanos has received grant/research support from Ortho-McNeil; has served as a consultant for Abbott Labs, Eli Lilly, Endo Pharmaceuticals, King, and Ortho-McNeil; and is on the speakers' bureau for Endo Pharmaceuticals, Eli Lilly, Ortho-McNeil, Pfizer, King, and Forest; Dr Treede has received grant/research support from Kade and Boehringer Ingelheim and has served as a consultant for Grünenthal, UCB, AWD pharma, GmbH & Co, and Kade; Dr Turk has received grant/research support from Endo Pharmaceuticals, Johnson & Johnson, and Philips Respironics and has served as a consultant for Eli Lilly, Johnson & Johnson, Philips Respironics, and SK Lifescience; Dr Walco has served as a consultant for Neuromed, Pfizer, and Purdue Pharma; Dr Wells has served as a consultant for Prostrachan and is on the speakers' bureau for Grünenthal, Napp (Purdue in the United States), and Pfizer.
PY - 2010/3
Y1 - 2010/3
N2 - The Neuropathic Pain Special Interest Group of the International Association for the Study of Pain recently sponsored the development of evidence-based guidelines for the pharmacological treatment of neuropathic pain. Tricyclic antidepressants, dual reuptake inhibitors of serotonin and norepinephrine, calcium channel α2-δ ligands (ie, gabapentin and pregabalin), and topical lidocaine were recommended as first-line treatment options on the basis of the results of randomized clinical trials. Opioid analgesics and tramadol were recommended as second-line treatments that can be considered for first-line use in certain clinical circumstances. Results of several recent clinical trials have become available since the development of these guidelines. These studies have examined botulinum toxin, high-concentration capsaicin patch, lacosamide, selective serotonin reuptake inhibitors, and combination therapies in various neuropathic pain conditions. The increasing number of negative clinical trials of pharmacological treatments for neuropathic pain and ambiguities in the interpretation of these negative trials must also be considered in developing treatment guidelines. The objectives of the current article are to review the Neuropathic Pain Special Interest Group guidelines for the pharmacological management of neuropathic pain and to provide a brief overview of these recent studies.
AB - The Neuropathic Pain Special Interest Group of the International Association for the Study of Pain recently sponsored the development of evidence-based guidelines for the pharmacological treatment of neuropathic pain. Tricyclic antidepressants, dual reuptake inhibitors of serotonin and norepinephrine, calcium channel α2-δ ligands (ie, gabapentin and pregabalin), and topical lidocaine were recommended as first-line treatment options on the basis of the results of randomized clinical trials. Opioid analgesics and tramadol were recommended as second-line treatments that can be considered for first-line use in certain clinical circumstances. Results of several recent clinical trials have become available since the development of these guidelines. These studies have examined botulinum toxin, high-concentration capsaicin patch, lacosamide, selective serotonin reuptake inhibitors, and combination therapies in various neuropathic pain conditions. The increasing number of negative clinical trials of pharmacological treatments for neuropathic pain and ambiguities in the interpretation of these negative trials must also be considered in developing treatment guidelines. The objectives of the current article are to review the Neuropathic Pain Special Interest Group guidelines for the pharmacological management of neuropathic pain and to provide a brief overview of these recent studies.
UR - http://www.scopus.com/inward/record.url?scp=77950367410&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950367410&partnerID=8YFLogxK
U2 - 10.4065/mcp.2009.0649
DO - 10.4065/mcp.2009.0649
M3 - Review article
C2 - 20194146
AN - SCOPUS:77950367410
VL - 85
SP - S3-S14
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
SN - 0025-6196
IS - 3 SUPPL.
ER -