Recommendations for measuring HIV reservoir size in cure-directed clinical trials

The BEAT-HIV Delaney Collaboratory to Cure HIV-1 infection

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Therapeutic strategies are being clinically tested either to eradicate latent HIV reservoirs or to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will require a consensus on how best to measure the numbers of persistently infected cells with the potential to cause viral rebound after antiretroviral-therapy cessation in assessing the results of cure-directed strategies in vivo. Current measurements assess various aspects of the HIV provirus and its functionality and produce divergent results. Here, we provide recommendations from the BEAT-HIV Martin Delaney Collaboratory on which viral measurements should be prioritized in HIV-cure-directed clinical trials.

Original languageEnglish (US)
Pages (from-to)1339-1350
Number of pages12
JournalNature medicine
Volume26
Issue number9
DOIs
StatePublished - Sep 1 2020

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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