Recombinant human platelet-derived growth factor-BB in human alveolar ridge augmentation: A review of the literature

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Purpose: The objective of this study was to review the available literature regarding the use of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in human alveolar ridge augmentation and to assess its effectiveness for this specific use. Materials and Methods: Three electronic searches of the MEDLINE database were performed. Results: This review noted a wide range of study protocols, carrier systems, study periods, and outcome measures. Conclusion: Within the limits of this literature review, the use of rhPDGF-BB and bone regeneration/ridge augmentation led to greater clinical attachment level gain and bone regeneration prior to implant placement. More controlled clinical studies are needed to establish the effectiveness of rhPDGF-BB in alveolar ridge augmentation.

Original languageEnglish (US)
Pages (from-to)1047-1056
Number of pages10
JournalInternational Journal of Oral and Maxillofacial Implants
Issue number5
Publication statusPublished - Jan 1 2018



  • alveolar ridge augmentation
  • Bone regeneration
  • Recombinant platelet-derived growth factor BB

ASJC Scopus subject areas

  • Oral Surgery

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