Recombinant human platelet-derived growth factor-BB in human alveolar ridge augmentation

A review of the literature

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: The objective of this study was to review the available literature regarding the use of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in human alveolar ridge augmentation and to assess its effectiveness for this specific use. Materials and Methods: Three electronic searches of the MEDLINE database were performed. Results: This review noted a wide range of study protocols, carrier systems, study periods, and outcome measures. Conclusion: Within the limits of this literature review, the use of rhPDGF-BB and bone regeneration/ridge augmentation led to greater clinical attachment level gain and bone regeneration prior to implant placement. More controlled clinical studies are needed to establish the effectiveness of rhPDGF-BB in alveolar ridge augmentation.

Original languageEnglish (US)
Pages (from-to)1047-1056
Number of pages10
JournalInternational Journal of Oral and Maxillofacial Implants
Volume33
Issue number5
DOIs
StatePublished - Jan 1 2018

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Alveolar Ridge Augmentation
Bone Regeneration
MEDLINE
Outcome Assessment (Health Care)
Databases
platelet-derived growth factor BB

Keywords

  • alveolar ridge augmentation
  • Bone regeneration
  • Recombinant platelet-derived growth factor BB
  • RhPDGF-BB

ASJC Scopus subject areas

  • Oral Surgery

Cite this

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title = "Recombinant human platelet-derived growth factor-BB in human alveolar ridge augmentation: A review of the literature",
abstract = "Purpose: The objective of this study was to review the available literature regarding the use of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in human alveolar ridge augmentation and to assess its effectiveness for this specific use. Materials and Methods: Three electronic searches of the MEDLINE database were performed. Results: This review noted a wide range of study protocols, carrier systems, study periods, and outcome measures. Conclusion: Within the limits of this literature review, the use of rhPDGF-BB and bone regeneration/ridge augmentation led to greater clinical attachment level gain and bone regeneration prior to implant placement. More controlled clinical studies are needed to establish the effectiveness of rhPDGF-BB in alveolar ridge augmentation.",
keywords = "alveolar ridge augmentation, Bone regeneration, Recombinant platelet-derived growth factor BB, RhPDGF-BB",
author = "Cynthia Scheines and Steven Hokett and Katancik, {James (Jim)}",
year = "2018",
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AU - Hokett, Steven

AU - Katancik, James (Jim)

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AB - Purpose: The objective of this study was to review the available literature regarding the use of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in human alveolar ridge augmentation and to assess its effectiveness for this specific use. Materials and Methods: Three electronic searches of the MEDLINE database were performed. Results: This review noted a wide range of study protocols, carrier systems, study periods, and outcome measures. Conclusion: Within the limits of this literature review, the use of rhPDGF-BB and bone regeneration/ridge augmentation led to greater clinical attachment level gain and bone regeneration prior to implant placement. More controlled clinical studies are needed to establish the effectiveness of rhPDGF-BB in alveolar ridge augmentation.

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