Recognition and delivery of effector proteins into eukaryotic cells by bacterial secretion systems

Eric Cambronne, Craig R. Roy

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The direct transport of virulence proteins from bacterium to host has emerged as a common strategy employed by Gram-negative pathogens to establish infections. Specialized secretion systems function to facilitate this process. The delivery of 'effector' proteins by these secretion systems is currently confined to two functionally similar but mechanistically distinct pathways, termed type III and type IV secretion. The type III secretion pathway is ancestrally related to the multiprotein complexes that assemble flagella, whereas the type IV mechanism probably emerged from the protein complexes that support conjugal transfer of DNA. Although both pathways serve to transport proteins from the bacterium to host, the recognition of the effector protein substrates and the secretion information contained in these proteins appear highly distinct. Here, we review the mechanisms involved in the selection of substrates by each of these transport systems and secretion signal information required for substrate transport.

Original languageEnglish (US)
Pages (from-to)929-939
Number of pages11
JournalTraffic
Volume7
Issue number8
DOIs
StatePublished - Aug 2006
Externally publishedYes

Fingerprint

Bacterial Secretion Systems
Eukaryotic Cells
Carrier Proteins
Bacteria
Multiprotein Complexes
Proteins
Substrates
Flagella
Secretory Pathway
Virulence
Pathogens
DNA
Infection

Keywords

  • Chaperone
  • Effector protein
  • Pathogenesis
  • Secretion signal
  • Type III secretion
  • Type IV secretion

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Structural Biology
  • Molecular Biology
  • Genetics

Cite this

Recognition and delivery of effector proteins into eukaryotic cells by bacterial secretion systems. / Cambronne, Eric; Roy, Craig R.

In: Traffic, Vol. 7, No. 8, 08.2006, p. 929-939.

Research output: Contribution to journalArticle

@article{97fa40e11ba44ee6b75a600d29f7832e,
title = "Recognition and delivery of effector proteins into eukaryotic cells by bacterial secretion systems",
abstract = "The direct transport of virulence proteins from bacterium to host has emerged as a common strategy employed by Gram-negative pathogens to establish infections. Specialized secretion systems function to facilitate this process. The delivery of 'effector' proteins by these secretion systems is currently confined to two functionally similar but mechanistically distinct pathways, termed type III and type IV secretion. The type III secretion pathway is ancestrally related to the multiprotein complexes that assemble flagella, whereas the type IV mechanism probably emerged from the protein complexes that support conjugal transfer of DNA. Although both pathways serve to transport proteins from the bacterium to host, the recognition of the effector protein substrates and the secretion information contained in these proteins appear highly distinct. Here, we review the mechanisms involved in the selection of substrates by each of these transport systems and secretion signal information required for substrate transport.",
keywords = "Chaperone, Effector protein, Pathogenesis, Secretion signal, Type III secretion, Type IV secretion",
author = "Eric Cambronne and Roy, {Craig R.}",
year = "2006",
month = "8",
doi = "10.1111/j.1600-0854.2006.00446.x",
language = "English (US)",
volume = "7",
pages = "929--939",
journal = "Traffic",
issn = "1398-9219",
publisher = "Blackwell Munksgaard",
number = "8",

}

TY - JOUR

T1 - Recognition and delivery of effector proteins into eukaryotic cells by bacterial secretion systems

AU - Cambronne, Eric

AU - Roy, Craig R.

PY - 2006/8

Y1 - 2006/8

N2 - The direct transport of virulence proteins from bacterium to host has emerged as a common strategy employed by Gram-negative pathogens to establish infections. Specialized secretion systems function to facilitate this process. The delivery of 'effector' proteins by these secretion systems is currently confined to two functionally similar but mechanistically distinct pathways, termed type III and type IV secretion. The type III secretion pathway is ancestrally related to the multiprotein complexes that assemble flagella, whereas the type IV mechanism probably emerged from the protein complexes that support conjugal transfer of DNA. Although both pathways serve to transport proteins from the bacterium to host, the recognition of the effector protein substrates and the secretion information contained in these proteins appear highly distinct. Here, we review the mechanisms involved in the selection of substrates by each of these transport systems and secretion signal information required for substrate transport.

AB - The direct transport of virulence proteins from bacterium to host has emerged as a common strategy employed by Gram-negative pathogens to establish infections. Specialized secretion systems function to facilitate this process. The delivery of 'effector' proteins by these secretion systems is currently confined to two functionally similar but mechanistically distinct pathways, termed type III and type IV secretion. The type III secretion pathway is ancestrally related to the multiprotein complexes that assemble flagella, whereas the type IV mechanism probably emerged from the protein complexes that support conjugal transfer of DNA. Although both pathways serve to transport proteins from the bacterium to host, the recognition of the effector protein substrates and the secretion information contained in these proteins appear highly distinct. Here, we review the mechanisms involved in the selection of substrates by each of these transport systems and secretion signal information required for substrate transport.

KW - Chaperone

KW - Effector protein

KW - Pathogenesis

KW - Secretion signal

KW - Type III secretion

KW - Type IV secretion

UR - http://www.scopus.com/inward/record.url?scp=33745736151&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745736151&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0854.2006.00446.x

DO - 10.1111/j.1600-0854.2006.00446.x

M3 - Article

VL - 7

SP - 929

EP - 939

JO - Traffic

JF - Traffic

SN - 1398-9219

IS - 8

ER -