Receptors for 5-hydroxytryptamine

Daniel H. Bobker, John T. Williams

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

5-Hydroxytryptamine (5-HT, serotonin) is an indolealkylamine that is found in multiple tissues of vertebrates and invertebrates. This chapter reviews the biochemistry, pharmacology, and physiology of 5-HT receptors. Each receptor subtype has a unique distribution. 5-HTIA receptors are located most densely in the limbic system, 5-HTIB in the striatum, 5-HTIC in the choroid plexus, 5-HT2 in the neocortex, and 5-HT3 in the area postrema. A consistently observed effect of 5-HTIA activation has been the modulation of adenylate cyclase activity. Both increases in basal cyclase and the inhibition of forskolin-stimulated cyclase activity have been reported. These discrepancies may have resulted from tissues that had more than one type of closely related 5-HT receptor. This problem has been surmounted by using mammalian cell lines that have no 5-HT receptors and transfecting them with the 5-HTIA gene.

Original languageEnglish (US)
Pages (from-to)221-250
Number of pages30
JournalNew Comprehensive Biochemistry
Volume24
Issue numberC
DOIs
StatePublished - Jan 1 1993

Keywords

  • 1-(2,5,-dimethoxy-4-bromophenyl)-2-aminopropane (DOB)
  • 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)
  • 1-(2-methoxyphenyl)4-[4-(2-phthalimido)butyI]piperazine(NAN-190)
  • 1-(3-chlorophenyl)piperazine (mCPP)
  • 1-(m-chloropheny1)-biguanide (mCBG)
  • 1-(m-trifluoromethylphenyl)piperazine(TFMPP)
  • 1-phenyl-biguanide (PBG)
  • 5-carboxamidotryptamine (5-CT)
  • 5-hydroxytryptamine (5-HT, serotonin)
  • 5-hydroxytryptophan (5-HTP)
  • 5-methoxytryptamine (5-MeOT)
  • 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)
  • GR-38032F (odansetron)
  • GTP-binding protein (G proteins)
  • choroid plexus (CP)
  • concentration causing 50% maximal effect (EC)
  • diacylglycerol (DAG)
  • dissociation constant (K)
  • dorsal raphe (DR)
  • hyperpolarization-activated current (I)
  • inhibitory postsynaptic potential (IPSP)
  • inositol-1,4,5-triphosphate (IP3)
  • lysergic acid diethylamide (LSD)
  • methylenedioxymethamphetamine (MDMA)
  • monoamine oxidase (MAO)
  • phosphatidylinositol (PI)
  • phospolipase C (PLC)
  • protein kinase C (PKC)
  • slow excitatory postsynaptic potential (sEPSP)
  • spiroperidol (spiperone)

ASJC Scopus subject areas

  • Biochemistry

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