Receptor-selective analogs demonstrate NPY/PYY receptor heterogeneity in rat brain

Sue A. Aicher, Mary Springston, Scott B. Berger, Donald J. Reis, Claes Wahlestedt

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


Neuropeptide Y (NPY) receptors are heterogeneous, consisting of at least two subclasses, Y1 and Y2. We sought evidence for differential expression of NPY receptor subtypes in the rat brain. Tissue was incubated with 125I-peptide YY (PYY) which labels NPY and PYY binding sites. The Y1-selective agonist, p[Pro34]NPY, and the Y2-selective agonist, pNPY 13-36, were used as displacing ligands. Autoradiographic analyses of regional receptor binding demonstrated heterogeneity across brain regions. We conclude that Y1- and Y2-receptors may be independently expressed in the brain. While the predominate NPY/PYY receptor subtype in the brain is Y2, there are also Y1-receptors in some brain regions such as the superficial layers of the parietal cortex.

Original languageEnglish (US)
Pages (from-to)32-36
Number of pages5
JournalNeuroscience Letters
Issue number1
StatePublished - Sep 2 1991
Externally publishedYes


  • Neuropeptide Y
  • Neuropeptide Y analogs
  • Receptor
  • Receptor autoradiography

ASJC Scopus subject areas

  • Neuroscience(all)


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