Recent progress in mammalian cloning

Don P. Wolf, L. I. Meng, John J. Ely, Richard Stouffer

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    Purpose: Our purpose was to review recent progress in the use of nuclear transfer technology to produce genetically identical mammals. Methods: A literature review was conducted. Results: The reasons for cloning nonhuman mammals are manyfold including commercial, biomedical, and basic research applications. Individual steps in the nuclear transfer process are itemized, along with a detailed description of the specific approaches used in the production of Dolly, NETI, and DITTO. The potential application of nuclear transfer in the treatment of human infertility is also considered, along with bioethical concerns. Finally, insights are provided concerning the future application of cloning technology in rhesus macaques. Conclusions: The cloning of a lamb (Dolly)from an adult, mammary gland cell coupled with the successful production of rhesus monkeys (NETI and DITTO) by nuclear transfer of embryonic cells marks the beginning of a 'Golden Age' in the development and application of somatic cell cloning technology in mammals.

    Original languageEnglish (US)
    Pages (from-to)235-239
    Number of pages5
    JournalJournal of Assisted Reproduction and Genetics
    Volume15
    Issue number5
    DOIs
    StatePublished - 1998

    Fingerprint

    Organism Cloning
    Mammals
    Macaca mulatta
    Technology
    Technology Transfer
    Human Mammary Glands
    Infertility
    Biomedical Research
    Therapeutics

    Keywords

    • Literature review
    • Mammalian cloning
    • Nuclear transfer technology

    ASJC Scopus subject areas

    • Obstetrics and Gynecology
    • Developmental Biology
    • Genetics
    • Reproductive Medicine

    Cite this

    Recent progress in mammalian cloning. / Wolf, Don P.; Meng, L. I.; Ely, John J.; Stouffer, Richard.

    In: Journal of Assisted Reproduction and Genetics, Vol. 15, No. 5, 1998, p. 235-239.

    Research output: Contribution to journalArticle

    Wolf, Don P. ; Meng, L. I. ; Ely, John J. ; Stouffer, Richard. / Recent progress in mammalian cloning. In: Journal of Assisted Reproduction and Genetics. 1998 ; Vol. 15, No. 5. pp. 235-239.
    @article{da742a4cc12a49eaabf805212006a654,
    title = "Recent progress in mammalian cloning",
    abstract = "Purpose: Our purpose was to review recent progress in the use of nuclear transfer technology to produce genetically identical mammals. Methods: A literature review was conducted. Results: The reasons for cloning nonhuman mammals are manyfold including commercial, biomedical, and basic research applications. Individual steps in the nuclear transfer process are itemized, along with a detailed description of the specific approaches used in the production of Dolly, NETI, and DITTO. The potential application of nuclear transfer in the treatment of human infertility is also considered, along with bioethical concerns. Finally, insights are provided concerning the future application of cloning technology in rhesus macaques. Conclusions: The cloning of a lamb (Dolly)from an adult, mammary gland cell coupled with the successful production of rhesus monkeys (NETI and DITTO) by nuclear transfer of embryonic cells marks the beginning of a 'Golden Age' in the development and application of somatic cell cloning technology in mammals.",
    keywords = "Literature review, Mammalian cloning, Nuclear transfer technology",
    author = "Wolf, {Don P.} and Meng, {L. I.} and Ely, {John J.} and Richard Stouffer",
    year = "1998",
    doi = "10.1023/A:1022575923493",
    language = "English (US)",
    volume = "15",
    pages = "235--239",
    journal = "Journal of Assisted Reproduction and Genetics",
    issn = "1058-0468",
    publisher = "Springer New York",
    number = "5",

    }

    TY - JOUR

    T1 - Recent progress in mammalian cloning

    AU - Wolf, Don P.

    AU - Meng, L. I.

    AU - Ely, John J.

    AU - Stouffer, Richard

    PY - 1998

    Y1 - 1998

    N2 - Purpose: Our purpose was to review recent progress in the use of nuclear transfer technology to produce genetically identical mammals. Methods: A literature review was conducted. Results: The reasons for cloning nonhuman mammals are manyfold including commercial, biomedical, and basic research applications. Individual steps in the nuclear transfer process are itemized, along with a detailed description of the specific approaches used in the production of Dolly, NETI, and DITTO. The potential application of nuclear transfer in the treatment of human infertility is also considered, along with bioethical concerns. Finally, insights are provided concerning the future application of cloning technology in rhesus macaques. Conclusions: The cloning of a lamb (Dolly)from an adult, mammary gland cell coupled with the successful production of rhesus monkeys (NETI and DITTO) by nuclear transfer of embryonic cells marks the beginning of a 'Golden Age' in the development and application of somatic cell cloning technology in mammals.

    AB - Purpose: Our purpose was to review recent progress in the use of nuclear transfer technology to produce genetically identical mammals. Methods: A literature review was conducted. Results: The reasons for cloning nonhuman mammals are manyfold including commercial, biomedical, and basic research applications. Individual steps in the nuclear transfer process are itemized, along with a detailed description of the specific approaches used in the production of Dolly, NETI, and DITTO. The potential application of nuclear transfer in the treatment of human infertility is also considered, along with bioethical concerns. Finally, insights are provided concerning the future application of cloning technology in rhesus macaques. Conclusions: The cloning of a lamb (Dolly)from an adult, mammary gland cell coupled with the successful production of rhesus monkeys (NETI and DITTO) by nuclear transfer of embryonic cells marks the beginning of a 'Golden Age' in the development and application of somatic cell cloning technology in mammals.

    KW - Literature review

    KW - Mammalian cloning

    KW - Nuclear transfer technology

    UR - http://www.scopus.com/inward/record.url?scp=0031946104&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0031946104&partnerID=8YFLogxK

    U2 - 10.1023/A:1022575923493

    DO - 10.1023/A:1022575923493

    M3 - Article

    C2 - 9604753

    AN - SCOPUS:0031946104

    VL - 15

    SP - 235

    EP - 239

    JO - Journal of Assisted Reproduction and Genetics

    JF - Journal of Assisted Reproduction and Genetics

    SN - 1058-0468

    IS - 5

    ER -