Recent progress in mammalian cloning

Don P. Wolf, L. I. Meng, John J. Ely, Richard L. Stouffer

    Research output: Contribution to journalArticle

    11 Scopus citations

    Abstract

    Purpose: Our purpose was to review recent progress in the use of nuclear transfer technology to produce genetically identical mammals. Methods: A literature review was conducted. Results: The reasons for cloning nonhuman mammals are manyfold including commercial, biomedical, and basic research applications. Individual steps in the nuclear transfer process are itemized, along with a detailed description of the specific approaches used in the production of Dolly, NETI, and DITTO. The potential application of nuclear transfer in the treatment of human infertility is also considered, along with bioethical concerns. Finally, insights are provided concerning the future application of cloning technology in rhesus macaques. Conclusions: The cloning of a lamb (Dolly)from an adult, mammary gland cell coupled with the successful production of rhesus monkeys (NETI and DITTO) by nuclear transfer of embryonic cells marks the beginning of a 'Golden Age' in the development and application of somatic cell cloning technology in mammals.

    Original languageEnglish (US)
    Pages (from-to)235-239
    Number of pages5
    JournalJournal of Assisted Reproduction and Genetics
    Volume15
    Issue number5
    DOIs
    StatePublished - May 27 1998

    Keywords

    • Literature review
    • Mammalian cloning
    • Nuclear transfer technology

    ASJC Scopus subject areas

    • Reproductive Medicine
    • Genetics
    • Obstetrics and Gynecology
    • Developmental Biology
    • Genetics(clinical)

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