Recent advances in alveolar biology: Some new looks at the alveolar interface

Fred Possmayer, Stephen (Steve) Hall, Thomas Haller, Nils O. Petersen, Yi Y. Zuo, Jorge Bernardino de la Serna, Anthony D. Postle, Ruud A W Veldhuizen, Sandra Orgeig

Research output: Contribution to journalArticle

32 Scopus citations


This article examines the manner in which some new methodologies and novel concepts have contributed to our understanding of how pulmonary surfactant reduces alveolar surface tension. Investigations utilizing small angle X-ray diffraction, inverted interface fluorescence microscopy, time of flight-secondary ion mass spectroscopy, atomic force microscopy, two-photon fluorescence microscopy and electrospray mass spectroscopy are highlighted and a new model of ventilation-induced acute lung injury described. This contribution attempts to emphasize how these new approaches have resulted in a fuller appreciation of events presumably occurring at the alveolar interface.

Original languageEnglish (US)
JournalRespiratory Physiology and Neurobiology
Issue numberSUPPL.
Publication statusPublished - Sep 2010



  • Acute respiratory distress
  • Fluorescence microscopy
  • Mass spectroscopy
  • Phospholipid metabolism
  • Pulmonary surfactant
  • X-ray diffraction

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

Cite this

Possmayer, F., Hall, S. S., Haller, T., Petersen, N. O., Zuo, Y. Y., Bernardino de la Serna, J., ... Orgeig, S. (2010). Recent advances in alveolar biology: Some new looks at the alveolar interface. Respiratory Physiology and Neurobiology, 173(SUPPL.).