Reanalysis of multislice 1h MRSI in amyotrophic lateral sclerosis

N. Schuff, W. D. Rooney, R. Miller, D. F. Gelinas, D. L. Amend, A. A. Maudsley, M. W. Weiner

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


The goal of this work was to reexamine previously published (1) brain spectroscopy data of abnormal metabolite ratios in amyotrophic lateral sclerosis (ALS). Toward this goal, 1H MR spectroscopic imaging data from 10 ALS and nine control subjects were reanalyzed using improved data analysis techniques, including automated curve fitting and tissue-volume correction. In the motor cortex of ALS, N-acetyl aspartate (NAA) was 23% (P = 0.004) lower than in controls, and in the posterior internal capsule of ALS choline compounds (Cho) were 20% (P = 0.02) higher. This demonstrates that the metabolite ratio changes in ALS were due to NAA loss in the motor cortex (as expected) and Cho increase in the posterior internal capsule (not expected).

Original languageEnglish (US)
Pages (from-to)513-516
Number of pages4
JournalMagnetic Resonance in Medicine
Issue number3
StatePublished - 2001
Externally publishedYes


  • Amyotrophic lateral sclerosis
  • Magnetic resonance spectroscopic imaging
  • Metabolite concentration
  • Motor cortex
  • N-acetyl aspartate

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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