Real-time treatment light dose guidance of Pleural PDT: An update

Timothy C. Zhu, Michele M. Kim, Steven L. Jacques, Rozhin Penjweini, Andreea Dimofte, Jarod C. Finlay, Charles B. Simone, Keith A. Cengel, Joseph Friedberg

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations

Abstract

The goal of this study was to develop and improve an infrared (IR) navigation system to deliver light dose uniformly during intracavitory PDT by tracking the movement of the light source and providing real-time feedback on the light fluence rate on the entire cavity surface area. In the current intrapleural PDT protocol, several detectors placed in selected locations in the pleural cavity monitor the light doses. To improve the delivery of light dose uniformity, an IR camera system is used to track the motion of the light source as well as the surface contour of the pleural cavity. Monte-Carlo simulation is used to improve the calculation algorithm for the effect of light that undergoes multiple scattering along the surface in addition to an improvement of the direct light calculation using an improved model that accounts for the anisotropy of the light from the light source.

Original languageEnglish (US)
Title of host publicationOptical Methods for Tumor Treatment and Detection
Subtitle of host publicationMechanisms and Techniques in Photodynamic Therapy XXIV
EditorsDavid H. Kessel, Tayyaba Hasan
PublisherSPIE
ISBN (Electronic)9781628413984
DOIs
StatePublished - Jan 1 2015
EventOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV - San Francisco, United States
Duration: Feb 7 2015Feb 9 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9308
ISSN (Print)1605-7422

Other

OtherOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV
CountryUnited States
CitySan Francisco
Period2/7/152/9/15

Keywords

  • MC simulation
  • Photodynamic therapy
  • intra-cavitary treatment planning
  • light dosimetry
  • light fluence

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Zhu, T. C., Kim, M. M., Jacques, S. L., Penjweini, R., Dimofte, A., Finlay, J. C., Simone, C. B., Cengel, K. A., & Friedberg, J. (2015). Real-time treatment light dose guidance of Pleural PDT: An update. In D. H. Kessel, & T. Hasan (Eds.), Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV [930809] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9308). SPIE. https://doi.org/10.1117/12.2080110