Real-time three-dimensional echocardiography for determining right ventricular stroke volume in an animal model of chronic right ventricular volume overload

Takahiro Shiota, Michael Jones, Masahide Chikada, Craig E. Fleishman, John B. Castellucci, Bruno Cotter, Anthony N. DeMaria, Olaf T. Von Ramm, Joseph Kisslo, Thomas Ryan, David J. Sahn

Research output: Contribution to journalArticlepeer-review

154 Scopus citations

Abstract

Background - The lack of a suitable noninvasive method for assessing right ventricular (RV) volume and function has been a major deficiency of two-dimensional (2D) echocardiography. The aim of our animal study was to test a new real-time three-dimensional (3D) echo imaging system for evaluating RV stroke volumes. Methods and Results - Three to 6 months before hemodynamic and 3D ultrasonic study, the pulmonary valve was excised from 6 sheep (31 to 59 kg) to induce RV volume overload. At the subsequent session, a total of 14 different steady-state hemodynamic conditions were studied. Electromagnetic (EM) flow probes were used for obtaining aortic and pulmonic flows. A unique phased-array volumetric 3D imaging system developed at the Duke University Center for Emerging Cardiovascular Technology was used for ultrasonic imaging. Real-time volumetric images of the RV were digitally stored, and RV stroke volumes were determined by use of parallel slices of the 3D RV data set and subtraction of end-systolic cavity volumes from end- diastolic cavity volumes. Multiple regression analyses showed a good correlation and agreement between the EM-obtained RV stroke volumes (range, 16 to 42 mL/beat) and those obtained by the new real-time 3D method (r=0.80; mean difference, -2.7±6.4 mL/beat). Conclusions - The real-time 3D system provided good estimation of strictly quantified reference RV stroke volumes, suggesting an important application of this new 3D method.

Original languageEnglish (US)
Pages (from-to)1897-1900
Number of pages4
JournalCirculation
Volume97
Issue number19
DOIs
StatePublished - May 19 1998

Keywords

  • Echocardiography
  • Imaging
  • Ventricles

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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