Reactome - A knowledgebase of biological pathways

Esther Schmidt, Ewan Birney, David Croft, Bernard De Bono, Peter D'Eustachio, Marc Gillespie, Gopal Gopinath, Bijay Jassal, Suzanna Lewis, Lisa Matthews, Lincoln Stein, Imre Vastrik, Guanming Wu

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations

Abstract

Reactome (www.reactome.org) is a curated database describing very diverse biological processes in a computationally accessible format. The data is provided by experts in the field and subject to a peer review process. The core unit of the Reactome data model is the reaction. The entities participating in reactions form a network of biological interactions. Reactions are grouped into pathways. Reactome data are cross-referenced to a wide selection of publically available databases (such as UniProt, Ensembl, GO, PubMed), facilitating overall integration of biological data. In addition to the manually curated, mainly human reactions, electronically inferred reactions to a wide range of other species, are presented on the website. All Reactome reactions are displayed as arrows on a Reactionmap. The Skypainter tool allows visualisation of user-supplied data by colouring the Reactionmap. Reactome data are freely available and can be downloaded in a number of formats.

Original languageEnglish (US)
Pages (from-to)710-719
Number of pages10
JournalLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4277 LNCS - I
DOIs
StatePublished - 2006
Externally publishedYes
EventOTM 2006 Workshops - OTM Confederated International Workshops - Montpellier, France
Duration: Oct 29 2006Nov 3 2006

Keywords

  • Biological processes
  • Knowledgebase
  • Pathways

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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