Reactive arthritis following culture-confirmed infections with bacterial enteric pathogens in Minnesota and Oregon: A population-based study

John Townes, Atulya (Atul) Deodhar, E. S. Laine, K. Smith, H. E. Krug, A. Barkhuizen, M. E. Thompson, P. R. Cieslak, J. Sobel

Research output: Contribution to journalArticle

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Abstract

Objective: To describe the epidemiology and clinical spectrum of reactive arthritis (ReA) following culture-confirmed infection with bacterial enteric pathogens in a population-based study in the USA. Methods: We conducted telephone interviews of persons age >1 year with culture confirmed Campylobacter, Escherichia coli O157, Salmonella, Shigella and Yersinia infections reported to FoodNet (http://www.cdc.gov/FoodNet/) in Minnesota, USA and Oregon, USA between 2002 and 2004. Subjects with new onset joint pain, joint swelling, back pain, heel pain and morning stiffness lasting ≥3 days within 8 weeks of culture (possible ReA) were invited to complete a detailed questionnaire and physical examination. Results: A total of 6379 culture-confirmed infections were reported; 70% completed screening interviews. Of these, 575 (13%) developed possible ReA; incidence was highest following Campylobacter (2.1/100 000) and Salmonella (1.4/100 000) infections. Risk was greater for females (relative risk (RR) 1.5, 95% CI, 1.3 to 1.7), adults (RR 2.5, 95% CI, 2.0 to 3.1) and subjects with severe acute illness (eg, fever, chills, headache, persistent diarrhoea). Risk was not associated with antibiotic use or human leukocyte antigen (HLA)-B27. A total of 54 (66%) of 82 subjects examined had confirmed ReA. Enthesitis was the most frequent finding; arthritis was less common. The estimated incidence of ReA following culture-confirmed Campylobacter, E coli O157, Salmonella, Shigella and Yersinia infections in Oregon was 0.6-3.1 cases/100 000. Conclusions: This is the first population-based study of ReA following infections due to bacterial enteric pathogens in the USA. These data will help determine the burden of illness due to these pathogens and inform clinicians about potential sequelae of these infections.

Original languageEnglish (US)
Pages (from-to)1689-1696
Number of pages8
JournalAnnals of the Rheumatic Diseases
Volume67
Issue number12
DOIs
StatePublished - Dec 2008

Fingerprint

Reactive Arthritis
Pathogens
Bacterial Infections
Salmonella
Yersinia Infections
Campylobacter coli
Escherichia coli
Population
Escherichia coli Infections
Shigella
Escherichia coli O157
Salmonella Infections
Infection
Epidemiology
HLA Antigens
Telephone
Interviews
Swelling
Chills
Screening

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

Cite this

Reactive arthritis following culture-confirmed infections with bacterial enteric pathogens in Minnesota and Oregon : A population-based study. / Townes, John; Deodhar, Atulya (Atul); Laine, E. S.; Smith, K.; Krug, H. E.; Barkhuizen, A.; Thompson, M. E.; Cieslak, P. R.; Sobel, J.

In: Annals of the Rheumatic Diseases, Vol. 67, No. 12, 12.2008, p. 1689-1696.

Research output: Contribution to journalArticle

Townes, John ; Deodhar, Atulya (Atul) ; Laine, E. S. ; Smith, K. ; Krug, H. E. ; Barkhuizen, A. ; Thompson, M. E. ; Cieslak, P. R. ; Sobel, J. / Reactive arthritis following culture-confirmed infections with bacterial enteric pathogens in Minnesota and Oregon : A population-based study. In: Annals of the Rheumatic Diseases. 2008 ; Vol. 67, No. 12. pp. 1689-1696.
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abstract = "Objective: To describe the epidemiology and clinical spectrum of reactive arthritis (ReA) following culture-confirmed infection with bacterial enteric pathogens in a population-based study in the USA. Methods: We conducted telephone interviews of persons age >1 year with culture confirmed Campylobacter, Escherichia coli O157, Salmonella, Shigella and Yersinia infections reported to FoodNet (http://www.cdc.gov/FoodNet/) in Minnesota, USA and Oregon, USA between 2002 and 2004. Subjects with new onset joint pain, joint swelling, back pain, heel pain and morning stiffness lasting ≥3 days within 8 weeks of culture (possible ReA) were invited to complete a detailed questionnaire and physical examination. Results: A total of 6379 culture-confirmed infections were reported; 70{\%} completed screening interviews. Of these, 575 (13{\%}) developed possible ReA; incidence was highest following Campylobacter (2.1/100 000) and Salmonella (1.4/100 000) infections. Risk was greater for females (relative risk (RR) 1.5, 95{\%} CI, 1.3 to 1.7), adults (RR 2.5, 95{\%} CI, 2.0 to 3.1) and subjects with severe acute illness (eg, fever, chills, headache, persistent diarrhoea). Risk was not associated with antibiotic use or human leukocyte antigen (HLA)-B27. A total of 54 (66{\%}) of 82 subjects examined had confirmed ReA. Enthesitis was the most frequent finding; arthritis was less common. The estimated incidence of ReA following culture-confirmed Campylobacter, E coli O157, Salmonella, Shigella and Yersinia infections in Oregon was 0.6-3.1 cases/100 000. Conclusions: This is the first population-based study of ReA following infections due to bacterial enteric pathogens in the USA. These data will help determine the burden of illness due to these pathogens and inform clinicians about potential sequelae of these infections.",
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AU - Laine, E. S.

AU - Smith, K.

AU - Krug, H. E.

AU - Barkhuizen, A.

AU - Thompson, M. E.

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