RBC lithium transport in the psychoses

Robert Hitzemann, Cynthia Mark, Jack Hirschowitz, David Garver

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Abstract

In vitro and in vivo red blood cell (RBC) lithium (Li + ) intracellularlextracellular ratios were determined in 93 DSM-III schizophrenics (SCZ) in 47 DSM-III schizophreniform disorder patients (SF), in 22 DSM-III bipolar manies (M), in 15 affective disorders patients with mood-incongruent psychotic features (AD-MIP), and in 40 normal controls. There were no significant differences among groups in the in vitro Li+ ratio. Similarly, there was no significant difference among patient groups in the in vivo Li+ ratio. Furthermore, there was no significant difference in the mean Li+ ratios between the Li+ -responsive and nonresponsive schizophrenic-like subjects. However, the distribution of Li+ ratios (both in vitro and in vivo) in the Li+ -responsive group was significantly abnormal, showing more ratios in the extremes of the distribution (a platykurtic distribution).

Original languageEnglish (US)
Pages (from-to)296-304
Number of pages9
JournalBiological Psychiatry
Volume25
Issue number3
DOIs
StatePublished - Feb 1 1989

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ASJC Scopus subject areas

  • Biological Psychiatry

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