TY - JOUR
T1 - RBC lithium transport in the psychoses
AU - Hitzemann, Robert
AU - Mark, Cynthia
AU - Hirschowitz, Jack
AU - Garver, David
N1 - Funding Information:
From the Depertment of Psychiatry and Behavioral Sciences, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8101 and the Psychiatry Service, VA Medical Center, Northport, (R.H., J.H.), and the Depatment of Psychiatry, University of Cincinnati, Cincinnati, OH (C.M.. D.G.). Supported in part by a grant from the Scottish Rite Schizophrenia Foundation and NIMH Grant MH-32777. Address reprint requests to Dr. Robert J. Hitzemann, SUNY at Stony Bmok, Health Sciences Center T-10, Stony Break, NY 11974-8101. Received December 26, 1987; revised March 11, 1988.
PY - 1989/2/1
Y1 - 1989/2/1
N2 - In vitro and in vivo red blood cell (RBC) lithium (Li + ) intracellularlextracellular ratios were determined in 93 DSM-III schizophrenics (SCZ) in 47 DSM-III schizophreniform disorder patients (SF), in 22 DSM-III bipolar manies (M), in 15 affective disorders patients with mood-incongruent psychotic features (AD-MIP), and in 40 normal controls. There were no significant differences among groups in the in vitro Li+ ratio. Similarly, there was no significant difference among patient groups in the in vivo Li+ ratio. Furthermore, there was no significant difference in the mean Li+ ratios between the Li+ -responsive and nonresponsive schizophrenic-like subjects. However, the distribution of Li+ ratios (both in vitro and in vivo) in the Li+ -responsive group was significantly abnormal, showing more ratios in the extremes of the distribution (a platykurtic distribution).
AB - In vitro and in vivo red blood cell (RBC) lithium (Li + ) intracellularlextracellular ratios were determined in 93 DSM-III schizophrenics (SCZ) in 47 DSM-III schizophreniform disorder patients (SF), in 22 DSM-III bipolar manies (M), in 15 affective disorders patients with mood-incongruent psychotic features (AD-MIP), and in 40 normal controls. There were no significant differences among groups in the in vitro Li+ ratio. Similarly, there was no significant difference among patient groups in the in vivo Li+ ratio. Furthermore, there was no significant difference in the mean Li+ ratios between the Li+ -responsive and nonresponsive schizophrenic-like subjects. However, the distribution of Li+ ratios (both in vitro and in vivo) in the Li+ -responsive group was significantly abnormal, showing more ratios in the extremes of the distribution (a platykurtic distribution).
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U2 - 10.1016/0006-3223(89)90177-7
DO - 10.1016/0006-3223(89)90177-7
M3 - Article
C2 - 2464376
AN - SCOPUS:0024533401
SN - 0006-3223
VL - 25
SP - 296
EP - 304
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 3
ER -