RBC lithium transport in the psychoses

Robert Hitzemann, Cynthia Mark, Jack Hirschowitz, David Garver

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In vitro and in vivo red blood cell (RBC) lithium (Li + ) intracellularlextracellular ratios were determined in 93 DSM-III schizophrenics (SCZ) in 47 DSM-III schizophreniform disorder patients (SF), in 22 DSM-III bipolar manies (M), in 15 affective disorders patients with mood-incongruent psychotic features (AD-MIP), and in 40 normal controls. There were no significant differences among groups in the in vitro Li+ ratio. Similarly, there was no significant difference among patient groups in the in vivo Li+ ratio. Furthermore, there was no significant difference in the mean Li+ ratios between the Li+ -responsive and nonresponsive schizophrenic-like subjects. However, the distribution of Li+ ratios (both in vitro and in vivo) in the Li+ -responsive group was significantly abnormal, showing more ratios in the extremes of the distribution (a platykurtic distribution).

Original languageEnglish (US)
Pages (from-to)296-304
Number of pages9
JournalBiological Psychiatry
Volume25
Issue number3
DOIs
StatePublished - Feb 1 1989
Externally publishedYes

Fingerprint

Lithium
Diagnostic and Statistical Manual of Mental Disorders
Psychotic Disorders
Erythrocytes
Mood Disorders
In Vitro Techniques

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

RBC lithium transport in the psychoses. / Hitzemann, Robert; Mark, Cynthia; Hirschowitz, Jack; Garver, David.

In: Biological Psychiatry, Vol. 25, No. 3, 01.02.1989, p. 296-304.

Research output: Contribution to journalArticle

Hitzemann, R, Mark, C, Hirschowitz, J & Garver, D 1989, 'RBC lithium transport in the psychoses', Biological Psychiatry, vol. 25, no. 3, pp. 296-304. https://doi.org/10.1016/0006-3223(89)90177-7
Hitzemann, Robert ; Mark, Cynthia ; Hirschowitz, Jack ; Garver, David. / RBC lithium transport in the psychoses. In: Biological Psychiatry. 1989 ; Vol. 25, No. 3. pp. 296-304.
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