Rate of bacteremia in the hemodialysis patient presenting to the emergency department with fever: a retrospective chart review

Nicholas Villalon, Neda Farzan, Kathryn Freeman

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Background: Infectious disease is the second most common cause of death in patients receiving hemodialysis (HD). When presenting to the emergency department (ED) with fever, it remains a diagnostic challenge to distinguish patients with potentially life-threatening bacterial infections from those with less significant causes of fever. The primary goal of this study was to determine the rate of bacteremia in HD patients presenting to the ED with fever. The secondary goal of this study was to identify any independent risk factors associated with bacteremia in the febrile HD patient. Methods: This is a retrospective medical record review of all HD patients who presented to the ED with either subjective fever as primary complaint or with a documented triage temperature of 38 °C or higher during the 3-year period between September 1, 2014, and September 1, 2017. Patient visits were included in the study if blood cultures were ordered in the ED. Data related to demographic information, clinical parameters, diagnostic test results in the ER, final diagnosis, and results of microbiology cultures were collected from each patient encounter. Univariate analysis was performed to identify risk factors associated with bacteremia. Results: We identified 353 patient visits from 138 unique patients that met inclusion criteria. Fifty-eight percent of these were women, and the average age was 54.6 years. The rate of bacteremia was 31.7%, and the main microorganisms isolated in blood culture were non-MRSA Staphylococcus aureus (40.7%), MRSA (13.3%), Pseudomonas aeruginosa (11.5%), and Enterobacter spp. (11.5%). Independent prognostic factors associated with bacteremia were use of dialysis catheter, prior history of bacteremia, and > 5% neutrophilic band cells (OR 6.55 [95% CI 3.96–10.8; p < 0.0001]; OR 8.87 [95% CI 5.32–14.8; p < 0.0001]; OR 3.32 [95% CI 1.90–5.80; p < 0.0001] respectively). Conclusion: HD patients presenting to the ED with fever have high rates of bacteremia, with a significantly higher rate in patients using dialysis catheters or those with a history of bacteremia. Other clinical data available in the ED is minimally useful in predicting bacteremia.

Original languageEnglish (US)
Article number29
JournalInternational Journal of Emergency Medicine
Issue number1
StatePublished - Dec 1 2018
Externally publishedYes


  • Bacteremia
  • Emergency department
  • Febrile
  • Fever
  • Hemodialysis
  • Sepsis

ASJC Scopus subject areas

  • Emergency Medicine


Dive into the research topics of 'Rate of bacteremia in the hemodialysis patient presenting to the emergency department with fever: a retrospective chart review'. Together they form a unique fingerprint.

Cite this