TY - JOUR
T1 - Rat model for a corneal basement membrane-type dystrophy
AU - Lyons, J. L.
AU - Rich, L. F.
AU - Baggia, S.
AU - Wilson, D. J.
AU - Rosenbaum, J. T.
PY - 1996/2/15
Y1 - 1996/2/15
N2 - Purpose: To determine clinical and histologic findings in Fisher rats that had an apparent corneal dystrophy. Methods: Numerous Fisher rats undergoing slit lamp examinations were incidentally found to have a corneal abnormality, present in the majority of rats seen. A set of 12 random Fisher rats of both genders (Bantin-Kingman, strain F344) were studied at the slit lamp, photographed, and the corneas examined histologically by H&E, PAS, trichrome, and Congo Red stains. Results: Of the 12 rats, all had bilateral numerous, small, nonvascular subepithelial white deposits over the central cornea. The opacities were a combination of linear and round. These lesions were seen when the rats were first examined at 2 months of age; although they appeared more opaque at a later age of 6 months, they did not change in location or configuration. Histologically, the basement membrane appears abnormal on PAS staining. Conclusions: These rats are an excellent animal model for an apparently autosomal dominant basement membrane-type corneal dystrophy. Further genetic, histologic, and ultrastructural studies are in progress to classify this dystrophy further, and to determine its relationship to a known human type of corneal dystrophy.
AB - Purpose: To determine clinical and histologic findings in Fisher rats that had an apparent corneal dystrophy. Methods: Numerous Fisher rats undergoing slit lamp examinations were incidentally found to have a corneal abnormality, present in the majority of rats seen. A set of 12 random Fisher rats of both genders (Bantin-Kingman, strain F344) were studied at the slit lamp, photographed, and the corneas examined histologically by H&E, PAS, trichrome, and Congo Red stains. Results: Of the 12 rats, all had bilateral numerous, small, nonvascular subepithelial white deposits over the central cornea. The opacities were a combination of linear and round. These lesions were seen when the rats were first examined at 2 months of age; although they appeared more opaque at a later age of 6 months, they did not change in location or configuration. Histologically, the basement membrane appears abnormal on PAS staining. Conclusions: These rats are an excellent animal model for an apparently autosomal dominant basement membrane-type corneal dystrophy. Further genetic, histologic, and ultrastructural studies are in progress to classify this dystrophy further, and to determine its relationship to a known human type of corneal dystrophy.
UR - http://www.scopus.com/inward/record.url?scp=33750148408&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750148408&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:33750148408
SN - 0146-0404
VL - 37
SP - S1016
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
IS - 3
ER -