Rapidly progressive sclerosing cholangitis following surgical treatment of pancreatic pseudotumor

George Stathopoulos, A. Daniel Nourmand, Michael Blackstone, Dana Andersen, Alfred L. Baker

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Two patients with sclerosing cholangitis presented with a distal stricture of the common bile duct in association with pancreatic pseudotumors. Jaundice resolved following surgery to correct biliary obstruction, but diffuse cholangio-graphic abnormalities and clinical evidence of sclerosing cholangitis became evident 2 and 4 months later. Rapid progression of symptomatic disease necessitated liver transplantation in one patient, but the other had a complete response to methotrexate therapy. The rapid disease progression in these two patients may have been triggered by surgery that resulted in a generalized fibroproliferative response of the biliary tree, already affected with localized sclerosing cholangitis contiguous to a pancreatic pseudotumor. We suggest that localized sclerosing cholangitis associated with pancreatic pseudo-tumors may be a unique variant that can progress rapidly but respond dramatically to antiinflammatory therapy.

Original languageEnglish (US)
Pages (from-to)143-148
Number of pages6
JournalJournal of Clinical Gastroenterology
Volume21
Issue number2
DOIs
StatePublished - Sep 1995

Keywords

  • Pancreatic pseudotumors
  • Sclerosing cholangitis

ASJC Scopus subject areas

  • Gastroenterology

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