Rapidly evolving adeno-associated virus vectors: Increasing possibility of gene therapy with custom-made vectors

Research output: Contribution to journalArticle

Abstract

Nature has evolved adeno-associated viruses (AAVs) very slowly by natural selection in their long history. However, since over 100 AAV serotypes and variants were discovered in primates in 2002, their evolution has been significantly accelerated by human intervention. Their simplest structure and ease of genetic manipulation have allowed exploitation of rational design and directed evolution approaches to create AAVs with desired properties. It has become possible to create custom-made AAV vectors for various experimental and therapeutic purposes.

Original languageEnglish (US)
Pages (from-to)582-591
Number of pages10
JournalDrug Delivery System
Volume24
Issue number6
DOIs
StatePublished - 2009
Externally publishedYes

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Dependovirus
Genetic Therapy
Genetic Structures
Genetic Selection
Primates
History
Therapeutics

Keywords

  • Adeno-associated virus
  • Custom-made vector
  • DNA shuffling
  • Gene therapy
  • Random peptide display

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

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