Rapid repair of injured gastric mucosa

S. Ito, E. R. Lacy, Michael Rutten

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

The morphology of the rat gastric mucosa superficially damaged by a 30-45 sec exposure to 100% ethanol caused over 99% of the luminal surface to be necrotic without extensive hemorrhage or hyperemia. However, this damaged area restituted or rapidly healed and the process was described. These findings were compared with in vitro gastric mucosae of bullfrogs and guinea pigs which were damaged with 1 or 1.25 M NaCl and allowed to restitute. The rat gastric mucosa showed evidence of cell migration within 5 min after ethanol damage and after 15 min as much as 50% of the denuded basement membrane was restituted. After 30 min about 75% of the mucosa was covered with cells and by 1 h there were only minor epithelial discontinuities. The in vitro frog mucosal restitution after hypertonic injury was slower and required 1-2 h to show appreciable cell migration and 4-6 h for completion of the repair process. Using chambered guinea pig gastric mucosa damaged with hypertonic NaCl restituted the necrotic surface almost as rapidly as the intact rat stomach necrotized with absolute ethanol. Since prostaglandin treatment did not prevent ethanol or hypertonic salt injury or affect the restitution process it was proposed that the term cytoprotection as it is generally used is not appropriate.

Original languageEnglish (US)
Pages (from-to)87-95
Number of pages9
JournalScandinavian Journal of Gastroenterology, Supplement
Volume19
Issue number101
StatePublished - 1984
Externally publishedYes

Fingerprint

Gastric Mucosa
Ethanol
Cell Movement
Guinea Pigs
Rana catesbeiana
Cytoprotection
Hyperemia
Wounds and Injuries
Basement Membrane
Anura
Prostaglandins
Stomach
Mucous Membrane
Salts
Hemorrhage
In Vitro Techniques

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Ito, S., Lacy, E. R., & Rutten, M. (1984). Rapid repair of injured gastric mucosa. Scandinavian Journal of Gastroenterology, Supplement, 19(101), 87-95.

Rapid repair of injured gastric mucosa. / Ito, S.; Lacy, E. R.; Rutten, Michael.

In: Scandinavian Journal of Gastroenterology, Supplement, Vol. 19, No. 101, 1984, p. 87-95.

Research output: Contribution to journalArticle

Ito, S, Lacy, ER & Rutten, M 1984, 'Rapid repair of injured gastric mucosa', Scandinavian Journal of Gastroenterology, Supplement, vol. 19, no. 101, pp. 87-95.
Ito, S. ; Lacy, E. R. ; Rutten, Michael. / Rapid repair of injured gastric mucosa. In: Scandinavian Journal of Gastroenterology, Supplement. 1984 ; Vol. 19, No. 101. pp. 87-95.
@article{7098dda8145a4372abc486f3a80f7a3f,
title = "Rapid repair of injured gastric mucosa",
abstract = "The morphology of the rat gastric mucosa superficially damaged by a 30-45 sec exposure to 100{\%} ethanol caused over 99{\%} of the luminal surface to be necrotic without extensive hemorrhage or hyperemia. However, this damaged area restituted or rapidly healed and the process was described. These findings were compared with in vitro gastric mucosae of bullfrogs and guinea pigs which were damaged with 1 or 1.25 M NaCl and allowed to restitute. The rat gastric mucosa showed evidence of cell migration within 5 min after ethanol damage and after 15 min as much as 50{\%} of the denuded basement membrane was restituted. After 30 min about 75{\%} of the mucosa was covered with cells and by 1 h there were only minor epithelial discontinuities. The in vitro frog mucosal restitution after hypertonic injury was slower and required 1-2 h to show appreciable cell migration and 4-6 h for completion of the repair process. Using chambered guinea pig gastric mucosa damaged with hypertonic NaCl restituted the necrotic surface almost as rapidly as the intact rat stomach necrotized with absolute ethanol. Since prostaglandin treatment did not prevent ethanol or hypertonic salt injury or affect the restitution process it was proposed that the term cytoprotection as it is generally used is not appropriate.",
author = "S. Ito and Lacy, {E. R.} and Michael Rutten",
year = "1984",
language = "English (US)",
volume = "19",
pages = "87--95",
journal = "Scandinavian Journal of Gastroenterology, Supplement",
issn = "0085-5928",
publisher = "Taylor and Francis Ltd.",
number = "101",

}

TY - JOUR

T1 - Rapid repair of injured gastric mucosa

AU - Ito, S.

AU - Lacy, E. R.

AU - Rutten, Michael

PY - 1984

Y1 - 1984

N2 - The morphology of the rat gastric mucosa superficially damaged by a 30-45 sec exposure to 100% ethanol caused over 99% of the luminal surface to be necrotic without extensive hemorrhage or hyperemia. However, this damaged area restituted or rapidly healed and the process was described. These findings were compared with in vitro gastric mucosae of bullfrogs and guinea pigs which were damaged with 1 or 1.25 M NaCl and allowed to restitute. The rat gastric mucosa showed evidence of cell migration within 5 min after ethanol damage and after 15 min as much as 50% of the denuded basement membrane was restituted. After 30 min about 75% of the mucosa was covered with cells and by 1 h there were only minor epithelial discontinuities. The in vitro frog mucosal restitution after hypertonic injury was slower and required 1-2 h to show appreciable cell migration and 4-6 h for completion of the repair process. Using chambered guinea pig gastric mucosa damaged with hypertonic NaCl restituted the necrotic surface almost as rapidly as the intact rat stomach necrotized with absolute ethanol. Since prostaglandin treatment did not prevent ethanol or hypertonic salt injury or affect the restitution process it was proposed that the term cytoprotection as it is generally used is not appropriate.

AB - The morphology of the rat gastric mucosa superficially damaged by a 30-45 sec exposure to 100% ethanol caused over 99% of the luminal surface to be necrotic without extensive hemorrhage or hyperemia. However, this damaged area restituted or rapidly healed and the process was described. These findings were compared with in vitro gastric mucosae of bullfrogs and guinea pigs which were damaged with 1 or 1.25 M NaCl and allowed to restitute. The rat gastric mucosa showed evidence of cell migration within 5 min after ethanol damage and after 15 min as much as 50% of the denuded basement membrane was restituted. After 30 min about 75% of the mucosa was covered with cells and by 1 h there were only minor epithelial discontinuities. The in vitro frog mucosal restitution after hypertonic injury was slower and required 1-2 h to show appreciable cell migration and 4-6 h for completion of the repair process. Using chambered guinea pig gastric mucosa damaged with hypertonic NaCl restituted the necrotic surface almost as rapidly as the intact rat stomach necrotized with absolute ethanol. Since prostaglandin treatment did not prevent ethanol or hypertonic salt injury or affect the restitution process it was proposed that the term cytoprotection as it is generally used is not appropriate.

UR - http://www.scopus.com/inward/record.url?scp=0021258742&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021258742&partnerID=8YFLogxK

M3 - Article

VL - 19

SP - 87

EP - 95

JO - Scandinavian Journal of Gastroenterology, Supplement

JF - Scandinavian Journal of Gastroenterology, Supplement

SN - 0085-5928

IS - 101

ER -