Rapid reorganization of the axonal cytoskeleton induced by a gamma diketone

Joy C. Zagoren, Michael J. Politis, Peter S. Spencer

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Microtubules and neurofilaments are the major components of nerve fiber axoplasm and are evenly distributed longitudinally. Rearrangement of this distribution can be induced by a number of chemicals, including 2,5-hexanedione (2,5-HD). Utilizing 2,5-HD, this study explores the earliest time points of observable rearrangement of the cytoskeletal elements. Intrafascicular injections into the sciatic nerve shows central accumulation of microtubules and peripheral relocation of neurofilaments within 1 min of injection, suggesting a direct effect of the toxin of these components.

Original languageEnglish (US)
Pages (from-to)162-164
Number of pages3
JournalBrain research
Issue number1
StatePublished - Jun 27 1983
Externally publishedYes


  • 2,5-hexandione
  • microtubules
  • neurofilaments
  • reorganization

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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