Rapid nuclear actions of growth hormone

P. Rotwein, A. M. Granowski, M. J. Thomas

    Research output: Contribution to journalArticlepeer-review

    31 Scopus citations

    Abstract

    The mechanisms by which growth hormone (GH) initiates its effect on growth are largely unknown. In this report we examine the acute actions of GH with a focus on the intracellular signaling pathways leading from the cell-surface GH receptor into the nucleus, and culminating in the activation of specific target genes. We show that in vivo GH treatment leads to the rapid appearance of tyrosine-phosphorylated nuclear proteins and the equally rapid induction of c-fos and insulin-like growth factor I gene transcription. A model is proposed for a GH-activated intracellular signal transduction pathway.

    Original languageEnglish (US)
    Pages (from-to)170-175
    Number of pages6
    JournalHormone Research
    Volume42
    Issue number4-5
    DOIs
    StatePublished - 1994

    Keywords

    • Gene regulation
    • Hormone action
    • Insulin-like growth factor I
    • STAT91
    • c-fos

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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