Rapid nuclear actions of growth hormone

P. Rotwein, A. M. Granowski, M. J. Thomas

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The mechanisms by which growth hormone (GH) initiates its effect on growth are largely unknown. In this report we examine the acute actions of GH with a focus on the intracellular signaling pathways leading from the cell-surface GH receptor into the nucleus, and culminating in the activation of specific target genes. We show that in vivo GH treatment leads to the rapid appearance of tyrosine-phosphorylated nuclear proteins and the equally rapid induction of c-fos and insulin-like growth factor I gene transcription. A model is proposed for a GH-activated intracellular signal transduction pathway.

Original languageEnglish (US)
Pages (from-to)170-175
Number of pages6
JournalHormone Research
Volume42
Issue number4-5
DOIs
StatePublished - Jan 1 1994

Keywords

  • Gene regulation
  • Hormone action
  • Insulin-like growth factor I
  • STAT91
  • c-fos

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Rotwein, P., Granowski, A. M., & Thomas, M. J. (1994). Rapid nuclear actions of growth hormone. Hormone Research, 42(4-5), 170-175. https://doi.org/10.1159/000184189