Rapid metabolic clearance of the catechol estrogen 2-hydroxyestrone

George R. Merriam, David D. Brandon, Shinzo Kono, S. Edward Davis, D. Lynn Loriaux, Mdrtimer B. Lipsett

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

The plasma metabolic clearance rate (MCRp) of 2-hydroxyestrone was measured in normal young adults by two methods: infusion of unlabeled 2-OHE1 to equilibrium with radioimmunoassay of plasma 2-OHE1 levels, and infusion of [3H]2-OHE1 to equilibrium with measurement of chromatographically purified plasma [3H]2-OHE1. MCR's were 40-70,000 L/day and 15-50,000 L/day, respectively. This is the highest known MCR for a naturally occurring steroid. The only measurable plasma metabolite of [3H]2-OHE1 co-migrated with 2-methoxyestrone. When [3H]2-OHE1 was incubated with blood samples in vitro, [3H]ξ-methoxyestrone was rapidly formed. Since this MCR is higher than cardiac output, clearance must occur primarily in the blood compartment, probably largely by the action of erythrocyte catechol-0-methyltransferase.

Original languageEnglish (US)
Pages (from-to)1211-1213
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume51
Issue number5
DOIs
StatePublished - Nov 1980

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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