Rapid identification of improved protein ligands using peptoid microarrays

Hyun Suk Lim, M. Muralidhar Reddy, Xiangshu Xiao, Johnnie Wilson, Rosemary Wilson, Steven Connell, Thomas Kodadek

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

A rapid array-based protocol is presented by which a modest affinity protein-binding small molecule can be appended to a library of peptoids via click chemistry. The array can then be screened for improved ligands that exhibit a higher affinity for the protein target.

Original languageEnglish (US)
Pages (from-to)3866-3869
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number14
DOIs
StatePublished - Jul 15 2009

Keywords

  • Click chemistry
  • Combinatorial chemistry
  • Library screening
  • Microarray
  • Peptoid

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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