Rapid effects of 17β-estradiol on male copulatory behaviors are not elicited by the novel membrane active estrogenic compound STX

Katherine R. Kaufman, Martin Kelly, Charles Roselli

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1 Citation (Scopus)

Abstract

Estrogens have been shown to rapidly promote male copulatory behaviors with a time-course that suggests rapid signaling events are involved. The present study tested the hypothesis that estrogen acts through a novel Gq protein-coupled membrane estrogen receptor (ER). Thus, either estradiol (E2), STX (a diphenylacrylamide compound that selectively activates a membrane ER pathway), or vehicle were administered acutely to castrated male rats that bore subcutaneous (sc) dihydrotestosterone implants to maintain genital sensitivity. Appetitive (level changes, genital investigation) and consummatory (mounts, intromissions, ejaculations) components of male sexual behavior were measured in a bilevel testing apparatus. Testing showed that E2 treatment promoted olfactory and mounting behaviors, but had no effect on motivation as measured by anticipatory level changes. STX treatment showed no effect on either component of male sexual behavior. These results support previous results that showed that E2 can rapidly affect male sexual behaviors but fail to support a role for the specific membrane-initiated pathway activated by STX.

Original languageEnglish (US)
Pages (from-to)598-605
Number of pages8
JournalBehavioral Neuroscience
Volume127
Issue number4
DOIs
StatePublished - Aug 2013

Fingerprint

Estradiol
Estrogens
Membranes
Sexual Behavior
Estrogen Receptors
Gq-G11 GTP-Binding Protein alpha Subunits
Ejaculation
Dihydrotestosterone
Motivation

Keywords

  • Bilevel test
  • Copulatory behavior
  • Estradiol
  • Mounting behavior
  • Olfactory behavior
  • Sexual motivation
  • STX

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

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abstract = "Estrogens have been shown to rapidly promote male copulatory behaviors with a time-course that suggests rapid signaling events are involved. The present study tested the hypothesis that estrogen acts through a novel Gq protein-coupled membrane estrogen receptor (ER). Thus, either estradiol (E2), STX (a diphenylacrylamide compound that selectively activates a membrane ER pathway), or vehicle were administered acutely to castrated male rats that bore subcutaneous (sc) dihydrotestosterone implants to maintain genital sensitivity. Appetitive (level changes, genital investigation) and consummatory (mounts, intromissions, ejaculations) components of male sexual behavior were measured in a bilevel testing apparatus. Testing showed that E2 treatment promoted olfactory and mounting behaviors, but had no effect on motivation as measured by anticipatory level changes. STX treatment showed no effect on either component of male sexual behavior. These results support previous results that showed that E2 can rapidly affect male sexual behaviors but fail to support a role for the specific membrane-initiated pathway activated by STX.",
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author = "Kaufman, {Katherine R.} and Martin Kelly and Charles Roselli",
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