Rapid development of disseminated superficial porokeratosis after transplant induction therapy

L. L. Fields, Clifton White, Richard Maziarz

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Disseminated superficial actinic porokeratosis (DSAP) is a cutaneous disorder, usually inherited in an autosomal dominant fashion, characterized by numerous annular papules with subtle raised hyperkeratotic borders and slightly atrophic centers. While the precise pathophysiologic mechanisms underlying the development of DSAP are unknown, one hypothesis is multifocal expansion of atypical clones of keratinocytes, perhaps unmasked by actinic damage, as implied by its name. Although primarily of cosmetic concern, there is an increased risk of squamous cell carcinoma of the skin developing within DSAP lesions, which often show histologic keratinocytic atypia centrally. Immunosuppression, which is a significant risk factor for secondary malignancies including cutaneous squamous cell carcinoma, is also a well-documented precipitant of porokeratosis. We report a 62-year-old man who developed DSAP in a widely and rapidly progressive manner within days of receiving total body radiation and high-dose induction chemotherapy as planned preparative therapy for an autologous peripheral blood stem cell transplant for relapsed high grade lymphoma. Our patient's eruption of DSAP highlights a little recognized cutaneous manifestation of aggressive bone marrow transplant induction therapy.

Original languageEnglish (US)
Pages (from-to)993-995
Number of pages3
JournalBone Marrow Transplantation
Volume15
Issue number6
StatePublished - 1995

Fingerprint

Porokeratosis
Transplants
Skin
Squamous Cell Carcinoma
Therapeutics
Skin Manifestations
Induction Chemotherapy
Keratinocytes
Cosmetics
Non-Hodgkin's Lymphoma
Immunosuppression
Names
Clone Cells
Bone Marrow
Radiation

Keywords

  • Disseminated
  • Rapid
  • Superficial porokeratosis

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Rapid development of disseminated superficial porokeratosis after transplant induction therapy. / Fields, L. L.; White, Clifton; Maziarz, Richard.

In: Bone Marrow Transplantation, Vol. 15, No. 6, 1995, p. 993-995.

Research output: Contribution to journalArticle

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