TY - JOUR
T1 - Rapid CD4+ T-Lymphocyte Depletion in Rhesus Monkeys Infected with a Simian-Human Immunodeficiency Virus Expressing the Envelope Glycoproteins of a Primary Dual-Tropic Ethiopian Clade C HIV Type 1 Isolate
AU - Cayabyab, Mark
AU - Rohne, Daniela
AU - Pollakis, Georgios
AU - Mische, Claudia
AU - Messele, Tseyanish
AU - Abebe, Almaz
AU - Etemad-Moghadam, Bijan
AU - Yang, Peter
AU - Henson, Scott
AU - Axthelm, Michael
AU - Goudsmit, Jaap
AU - Letvin, Norman L.
AU - Sodroski, Joseph
PY - 2004/1
Y1 - 2004/1
N2 - Simian-human immunodeficiency virus (SHIV) chimerae with the envelope glycoproteins of X4 or R5/X4 HIV-1 isolates from clade B can cause rapid and severe CD4+ T cell depletion and AIDS-like illness in infected monkeys. We created a SHIV (SHIV-MCGP1.3) expressing the envelope glycoproteins of a primary R5/X4, clade C HIV-1 isolate. Infection of a rhesus monkey with SHIV-MCGP1.3 resulted in a low level of viremia and no significant alteration in CD4+ T-lymphocyte counts. However, serial intravenous passage of the virus resulted in the emergence of SHIV-MCGP1.3 variants that replicated efficiently and caused profound CD4+ T cell depletion during the acute phase of infection. The CD4+ T cell counts in the infected monkeys gradually returned to normal, and the animals remained healthy. The ability to cause rapid and profound loss of CD4+ T lymphocytes in vivo is a property shared by passaged, CXCR4-using SHIVs, irrespective of the clade of origin of the HIV-1 envelope glycoproteins.
AB - Simian-human immunodeficiency virus (SHIV) chimerae with the envelope glycoproteins of X4 or R5/X4 HIV-1 isolates from clade B can cause rapid and severe CD4+ T cell depletion and AIDS-like illness in infected monkeys. We created a SHIV (SHIV-MCGP1.3) expressing the envelope glycoproteins of a primary R5/X4, clade C HIV-1 isolate. Infection of a rhesus monkey with SHIV-MCGP1.3 resulted in a low level of viremia and no significant alteration in CD4+ T-lymphocyte counts. However, serial intravenous passage of the virus resulted in the emergence of SHIV-MCGP1.3 variants that replicated efficiently and caused profound CD4+ T cell depletion during the acute phase of infection. The CD4+ T cell counts in the infected monkeys gradually returned to normal, and the animals remained healthy. The ability to cause rapid and profound loss of CD4+ T lymphocytes in vivo is a property shared by passaged, CXCR4-using SHIVs, irrespective of the clade of origin of the HIV-1 envelope glycoproteins.
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U2 - 10.1089/088922204322749477
DO - 10.1089/088922204322749477
M3 - Article
C2 - 15000696
AN - SCOPUS:9144221350
SN - 0889-2229
VL - 20
SP - 27
EP - 40
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
IS - 1
ER -