Rapid CD4+ T-Lymphocyte Depletion in Rhesus Monkeys Infected with a Simian-Human Immunodeficiency Virus Expressing the Envelope Glycoproteins of a Primary Dual-Tropic Ethiopian Clade C HIV Type 1 Isolate

Mark Cayabyab, Daniela Rohne, Georgios Pollakis, Claudia Mische, Tseyanish Messele, Almaz Abebe, Bijan Etemad-Moghadam, Peter Yang, Scott Henson, Michael Axthelm, Jaap Goudsmit, Norman L. Letvin, Joseph Sodroski

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    Abstract

    Simian-human immunodeficiency virus (SHIV) chimerae with the envelope glycoproteins of X4 or R5/X4 HIV-1 isolates from clade B can cause rapid and severe CD4+ T cell depletion and AIDS-like illness in infected monkeys. We created a SHIV (SHIV-MCGP1.3) expressing the envelope glycoproteins of a primary R5/X4, clade C HIV-1 isolate. Infection of a rhesus monkey with SHIV-MCGP1.3 resulted in a low level of viremia and no significant alteration in CD4+ T-lymphocyte counts. However, serial intravenous passage of the virus resulted in the emergence of SHIV-MCGP1.3 variants that replicated efficiently and caused profound CD4+ T cell depletion during the acute phase of infection. The CD4+ T cell counts in the infected monkeys gradually returned to normal, and the animals remained healthy. The ability to cause rapid and profound loss of CD4+ T lymphocytes in vivo is a property shared by passaged, CXCR4-using SHIVs, irrespective of the clade of origin of the HIV-1 envelope glycoproteins.

    Original languageEnglish (US)
    Pages (from-to)27-40
    Number of pages14
    JournalAIDS Research and Human Retroviruses
    Volume20
    Issue number1
    DOIs
    Publication statusPublished - Jan 2004

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    ASJC Scopus subject areas

    • Immunology
    • Virology

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