Rapid and sensitive LC-MS approach to quantify non-radioactive transition metal impurities in metal radionuclides

Dexing Zeng; Carolyn J. Anderson

doi:10.1039/c3cc39071c

Rapid and sensitive LC-MS approach to quantify non-radioactive transition metal impurities in metal radionuclides

Dexing Zeng, Carolyn J. Anderson

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A rapid and sensitive LC-MS approach for the quantification of non-radioactive metal contaminants present in metal radionuclide formulations was developed. Traditional ¹²C/¹H and heavy stable isotope ¹³C/²H-labeled chelator–amino acid conjugates are used as chelating agents to quantify contaminating transition metals, allowing for determination of effective specific activity of radio-metals.

Original language	English (US)
Pages (from-to)	2697-2699
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	26
DOIs	https://doi.org/10.1039/c3cc39071c
State	Published - Mar 5 2013
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c3cc39071c

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abstract = "A rapid and sensitive LC-MS approach for the quantification of non-radioactive metal contaminants present in metal radionuclide formulations was developed. Traditional 12C/1H and heavy stable isotope 13C/2H-labeled chelator–amino acid conjugates are used as chelating agents to quantify contaminating transition metals, allowing for determination of effective specific activity of radio-metals.",

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AB - A rapid and sensitive LC-MS approach for the quantification of non-radioactive metal contaminants present in metal radionuclide formulations was developed. Traditional 12C/1H and heavy stable isotope 13C/2H-labeled chelator–amino acid conjugates are used as chelating agents to quantify contaminating transition metals, allowing for determination of effective specific activity of radio-metals.

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JO - Chemical Communications

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Rapid and sensitive LC-MS approach to quantify non-radioactive transition metal impurities in metal radionuclides

Abstract

ASJC Scopus subject areas

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