Rapid actions of plasma membrane estrogen receptors

Martin Kelly, Ellis R. Levin

Research output: Contribution to journalArticle

539 Citations (Scopus)

Abstract

Functional evidence for the existence of plasma membrane estrogen receptors in a variety of cell types continues to accumulate. Many of these functions originate from rapid signaling events, transduced in response to 17β-estradiol (E2). It has been convincingly shown that E2 activates phosphoinositol 3-kinase and protein kinase B/AKT, and stimulates ERK and p38 MAP kinases. In part, this stems from G-protein activation and the resulting calcium flux. As a result, the link between E2 action at the cell membrane and discrete biological actions in the cell has been strengthened. There is now convincing in vitro evidence that E2 can modulate the functions of neural and vascular cells via non-genomic actions. Thus, the actions of discrete pools of E2 receptors are likely to contribute to the overall effects of the sex steroids.

Original languageEnglish (US)
Pages (from-to)152-156
Number of pages5
JournalTrends in Endocrinology and Metabolism
Volume12
Issue number4
StatePublished - 2001

Fingerprint

Estrogen Receptors
Cell Membrane
Proto-Oncogene Proteins c-akt
Extracellular Signal-Regulated MAP Kinases
p38 Mitogen-Activated Protein Kinases
GTP-Binding Proteins
Blood Vessels
Estradiol
Phosphotransferases
Steroids
Calcium
In Vitro Techniques

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Rapid actions of plasma membrane estrogen receptors. / Kelly, Martin; Levin, Ellis R.

In: Trends in Endocrinology and Metabolism, Vol. 12, No. 4, 2001, p. 152-156.

Research output: Contribution to journalArticle

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