Rap1: Selective activator of β2 integrins?

Research output: Contribution to journalArticle

Abstract

In T cells, Rap1 is well-recognized as a major mediator of inside-out signaling to integrins following stimulation by antigen and chemokines. Ghandour and colleagues have identified a selective role for Rap1 in human T cells in chemokine-dependent adhesion via LFA-1, but not VLA-4. Their study highlights the specificity of Rap1 for LFA-1 in SDF-1α-mediated adhesion, and shows that PLC and the Rap1 exchanger CalDAG-GEFI are required.

Original languageEnglish (US)
Pages (from-to)3496-3497
Number of pages2
JournalBlood
Volume110
Issue number10
DOIs
StatePublished - Nov 15 2007

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Lymphocyte Function-Associated Antigen-1
T-cells
Chemokines
Integrins
Adhesion
Integrin alpha4beta1
T-Lymphocytes
Programmable logic controllers
Antigens

ASJC Scopus subject areas

  • Hematology

Cite this

Rap1 : Selective activator of β2 integrins? / Stork, Philip.

In: Blood, Vol. 110, No. 10, 15.11.2007, p. 3496-3497.

Research output: Contribution to journalArticle

Stork, Philip. / Rap1 : Selective activator of β2 integrins?. In: Blood. 2007 ; Vol. 110, No. 10. pp. 3496-3497.
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