Rap1: Selective activator of β2 integrins?

Research output: Contribution to journalReview article

Abstract

In T cells, Rap1 is well-recognized as a major mediator of inside-out signaling to integrins following stimulation by antigen and chemokines. Ghandour and colleagues have identified a selective role for Rap1 in human T cells in chemokine-dependent adhesion via LFA-1, but not VLA-4. Their study highlights the specificity of Rap1 for LFA-1 in SDF-1α-mediated adhesion, and shows that PLC and the Rap1 exchanger CalDAG-GEFI are required.

Original languageEnglish (US)
Pages (from-to)3496-3497
Number of pages2
JournalBlood
Volume110
Issue number10
DOIs
StatePublished - Nov 15 2007

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ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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