Abstract
In T cells, Rap1 is well-recognized as a major mediator of inside-out signaling to integrins following stimulation by antigen and chemokines. Ghandour and colleagues have identified a selective role for Rap1 in human T cells in chemokine-dependent adhesion via LFA-1, but not VLA-4. Their study highlights the specificity of Rap1 for LFA-1 in SDF-1α-mediated adhesion, and shows that PLC and the Rap1 exchanger CalDAG-GEFI are required.
Original language | English (US) |
---|---|
Pages (from-to) | 3496-3497 |
Number of pages | 2 |
Journal | Blood |
Volume | 110 |
Issue number | 10 |
DOIs | |
State | Published - Nov 15 2007 |
ASJC Scopus subject areas
- Biochemistry
- Immunology
- Hematology
- Cell Biology