Randomized trial to assess the impact of venlafaxine and soy protein on hot flashes and quality of life in men with prostate cancer

Mara Z. Vitolins, Leah Griffin, W. Vic Tomlinson, Jacqueline Vuky, Paul T. Adams, Dawn Moose, Bart Frizzell, Glenn J. Lesser, Michelle Naughton, James E. Radford, Edward G. Shaw

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Purpose: Hot flashes occur in approximately 80% of androgen-deprived men. Few intervention studies have been conducted to relieve hot flashes in men. Patients and Methods: Eligible androgen-deprived men were randomly assigned to one of four daily regimens (2 × 2 factorial design) for 12 weeks: milk protein powder and placebo pill, venlafaxine and milk protein powder, soy protein powder and placebo pill, or venlafaxine and soy protein powder. The primary end point was hot flash symptom severity score (HFSSS), defined as number of hot flashes times severity. The secondary end point was quality of life (QoL), assessed by using the Functional Assessment of Cancer Therapy-Prostate. Results: In all, 120 men age 46 to 91 years participated. Most were white (78%) and overweight or obese (83%). Toxicity was minimal. Neither venlafaxine nor soy protein alone or in combination had a significant effect on HFSSS. Soy protein, but not venlafaxine, improved measures of QoL. Conclusion: In androgen-deprived men, neither venlafaxine nor soy proved effective in reducing hot flashes. Interventions that appear effective for decreasing hot flashes in women may not always turn out to be effective in men.

Original languageEnglish (US)
Pages (from-to)4092-4098
Number of pages7
JournalJournal of Clinical Oncology
Volume31
Issue number32
DOIs
StatePublished - Nov 10 2013

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Randomized trial to assess the impact of venlafaxine and soy protein on hot flashes and quality of life in men with prostate cancer'. Together they form a unique fingerprint.

  • Cite this

    Vitolins, M. Z., Griffin, L., Tomlinson, W. V., Vuky, J., Adams, P. T., Moose, D., Frizzell, B., Lesser, G. J., Naughton, M., Radford, J. E., & Shaw, E. G. (2013). Randomized trial to assess the impact of venlafaxine and soy protein on hot flashes and quality of life in men with prostate cancer. Journal of Clinical Oncology, 31(32), 4092-4098. https://doi.org/10.1200/JCO.2012.48.1432