Randomized comparison of intravenous terbutaline vs nitroglycerin for acute intrapartum fetal resuscitation

Kristin M. Pullen, Edward T. Riley, Sarah A. Waller, Larisa Taylor, Aaron Caughey, Maurice L. Druzin, Yasser Y. El-Sayed

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: The purpose of this study was to compare terbutaline and nitroglycerin for acute intrapartum fetal resuscitation. Study Design: Women between 32-, 42 weeks' gestation were assigned randomly to 250 μg of terbutaline or 400 μg nitroglycerin intravenously for nonreassuring fetal heart rate tracings in labor. The rate of successful acute intrapartum fetal resuscitation and the maternal hemodynamic changes were compared. Assuming a 50% failure rate in the terbutaline arm, we calculated that a total of 110 patients would be required to detect a 50% reduction in failure in the nitroglycerin group (50% to 25%), with an alpha value of .05, a beta value of .20, and a power of 80%. Results: One hundred ten women had nonreassuring fetal heart rate tracings in labor; 57 women received terbutaline, and 53 women received nitroglycerin. Successful acute resuscitation rates were similar (terbutaline 71.9% and nitroglycerin 64.2%; P = .38). Terbutaline resulted in lower median contraction frequency per 10 minutes (2.9 [25-75 percentile, 1.7- 3.3] vs 4 [25-75 percentile, 2.5- 5]; P <.002) and reduced tachysystole (1.8% vs 18.9%; P = .003). Maternal mean arterial pressures decreased with nitroglycerin (81-76 mm Hg; P = .02), but not terbutaline (82-81 mm Hg; P = .73). Conclusion: Although terbutaline provided more effective tocolysis with less impact on maternal blood pressure, no difference was noted between nitroglycerin and terbutaline in successful acute intrapartum fetal resuscitation.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume197
Issue number4
DOIs
StatePublished - Oct 2007
Externally publishedYes

Fingerprint

Terbutaline
Nitroglycerin
Resuscitation
Fetal Heart Rate
Mothers
Tocolysis
Arterial Pressure
Hemodynamics
Blood Pressure
Pregnancy

Keywords

  • intrapartum fetal resuscitation
  • nitroglycerin
  • nonreassuring fetal heart rate
  • terbutaline
  • tocolysis

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Randomized comparison of intravenous terbutaline vs nitroglycerin for acute intrapartum fetal resuscitation. / Pullen, Kristin M.; Riley, Edward T.; Waller, Sarah A.; Taylor, Larisa; Caughey, Aaron; Druzin, Maurice L.; El-Sayed, Yasser Y.

In: American Journal of Obstetrics and Gynecology, Vol. 197, No. 4, 10.2007.

Research output: Contribution to journalArticle

Pullen, Kristin M. ; Riley, Edward T. ; Waller, Sarah A. ; Taylor, Larisa ; Caughey, Aaron ; Druzin, Maurice L. ; El-Sayed, Yasser Y. / Randomized comparison of intravenous terbutaline vs nitroglycerin for acute intrapartum fetal resuscitation. In: American Journal of Obstetrics and Gynecology. 2007 ; Vol. 197, No. 4.
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abstract = "Objective: The purpose of this study was to compare terbutaline and nitroglycerin for acute intrapartum fetal resuscitation. Study Design: Women between 32-, 42 weeks' gestation were assigned randomly to 250 μg of terbutaline or 400 μg nitroglycerin intravenously for nonreassuring fetal heart rate tracings in labor. The rate of successful acute intrapartum fetal resuscitation and the maternal hemodynamic changes were compared. Assuming a 50{\%} failure rate in the terbutaline arm, we calculated that a total of 110 patients would be required to detect a 50{\%} reduction in failure in the nitroglycerin group (50{\%} to 25{\%}), with an alpha value of .05, a beta value of .20, and a power of 80{\%}. Results: One hundred ten women had nonreassuring fetal heart rate tracings in labor; 57 women received terbutaline, and 53 women received nitroglycerin. Successful acute resuscitation rates were similar (terbutaline 71.9{\%} and nitroglycerin 64.2{\%}; P = .38). Terbutaline resulted in lower median contraction frequency per 10 minutes (2.9 [25-75 percentile, 1.7- 3.3] vs 4 [25-75 percentile, 2.5- 5]; P <.002) and reduced tachysystole (1.8{\%} vs 18.9{\%}; P = .003). Maternal mean arterial pressures decreased with nitroglycerin (81-76 mm Hg; P = .02), but not terbutaline (82-81 mm Hg; P = .73). Conclusion: Although terbutaline provided more effective tocolysis with less impact on maternal blood pressure, no difference was noted between nitroglycerin and terbutaline in successful acute intrapartum fetal resuscitation.",
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