TY - JOUR
T1 - Randomised controlled trial of interventions for bothersome tinnitus
T2 - DesyncraTM versus cognitive behavioural therapy
AU - Theodoroff, Sarah M.
AU - McMillan, Garnett P.
AU - Schmidt, Caroline J.
AU - Dann, Serena M.
AU - Hauptmann, Christian
AU - Goodworth, Marie Christine
AU - Leibowitz, Ruth Q.
AU - Random, Chan
AU - Henry, James A.
N1 - Publisher Copyright:
©, This work was authored as part of the Contributor's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.
PY - 2022
Y1 - 2022
N2 - Objective: Compare the relative efficacy of DesyncraTM and Cognitive Behavioural Therapy (CBT). Design and study sample: Sixty-one participants were randomly assigned to receive either DesyncraTM (n = 29) or CBT (n = 32). Randomisation included stratification regarding current hearing aid (HA) use. Depending on group assignment, participants attended approximately 7–12 visits. Tinnitus distress was measured using the Tinnitus Questionnaire (TQ). Results: Mean TQ scores decreased post-baseline from 5–15 points across treatment arms and strata. Model-based findings for the no-HA stratum showed a difference of −2.0 TQ points favouring Desyncra at 24-weeks, with a 90% posterior interval varying from −5.4 points favouring Desyncra to 0.8 TQ points favouring CBT. For the HA stratum, results show a difference of −1.0 TQ points favouring Desyncra, with a 90% posterior interval ranging from −4.7 points favouring Desyncra to 2.9 points favouring CBT. Conclusions: The difference between Desyncra and CBT on average showed greater improvement with Desyncra in the no-HA stratum by about 2 TQ points. To the extent that the study sample represents a clinical population and recognising the assumptions in the design and analysis, these results suggest Desyncra is just as effective or more so than CBT in reducing tinnitus distress.
AB - Objective: Compare the relative efficacy of DesyncraTM and Cognitive Behavioural Therapy (CBT). Design and study sample: Sixty-one participants were randomly assigned to receive either DesyncraTM (n = 29) or CBT (n = 32). Randomisation included stratification regarding current hearing aid (HA) use. Depending on group assignment, participants attended approximately 7–12 visits. Tinnitus distress was measured using the Tinnitus Questionnaire (TQ). Results: Mean TQ scores decreased post-baseline from 5–15 points across treatment arms and strata. Model-based findings for the no-HA stratum showed a difference of −2.0 TQ points favouring Desyncra at 24-weeks, with a 90% posterior interval varying from −5.4 points favouring Desyncra to 0.8 TQ points favouring CBT. For the HA stratum, results show a difference of −1.0 TQ points favouring Desyncra, with a 90% posterior interval ranging from −4.7 points favouring Desyncra to 2.9 points favouring CBT. Conclusions: The difference between Desyncra and CBT on average showed greater improvement with Desyncra in the no-HA stratum by about 2 TQ points. To the extent that the study sample represents a clinical population and recognising the assumptions in the design and analysis, these results suggest Desyncra is just as effective or more so than CBT in reducing tinnitus distress.
KW - Bayesian analysis
KW - Tinnitus
KW - randomised controlled trial
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U2 - 10.1080/14992027.2021.2004325
DO - 10.1080/14992027.2021.2004325
M3 - Article
C2 - 34851208
AN - SCOPUS:85120668963
SN - 1499-2027
VL - 61
SP - 1035
EP - 1044
JO - International journal of audiology
JF - International journal of audiology
IS - 12
ER -