Random anti-Müllerian hormone (AMH) is a predictor of ovarian response in women with elevated baseline early follicular follicle-stimulating hormone levels

Erkan Buyuk, David Seifer, Joshua Younger, Richard V. Grazi, Harry Lieman

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Objective: To investigate the utility of random anti-Müllerian hormone (AMH) in assessing ovarian response among women with diminished ovarian reserve (DOR) diagnosed by elevated early follicular-phase FSH levels. Design: Retrospective study. Setting: Academic and academically affiliated assisted reproductive technology (ART) programs. Patient(s): Seventy-three women undergoing ART with elevated early follicular FSH levels. Intervention(s): None. Main Outcome Measure(s): Number of oocytes retrieved during ART cycle, number of day 3 embryos, and cycle cancellation and clinical pregnancy rates. Result(s): Random AMH levels were strongly correlated with the number of oocytes retrieved during an ART cycle among women with elevated FSH (r = 0.55). Women with elevated FSH who had a random serum AMH level of 0.6 ng/mL or higher had twice the number of oocytes retrieved (11 ± 1.3 vs. 5.6 ± 0.6), a greater number of day 3 embryos (5.7 ± 0.9 vs. 3 ± 0.5), and approximately a third of the cycle cancellation rate (14% vs. 41%) compared with women with a random serum AMH below 0.6 ng/mL. The clinical pregnancy rate was also higher among women with a random serum AMH ≥0.6 ng/mL (28% vs. 14%), however, the difference was not statistically significant. Conclusion(s): A random serum AMH level is useful in setting expectations for ART prognosis in women with elevated early follicular-phase serum FSH levels.

Original languageEnglish (US)
Pages (from-to)2369-2372
Number of pages4
JournalFertility and Sterility
Volume95
Issue number7
DOIs
StatePublished - Jun 2011
Externally publishedYes

Fingerprint

Follicle Stimulating Hormone
Assisted Reproductive Techniques
Hormones
Oocytes
Serum
Follicular Phase
Pregnancy Rate
Embryonic Structures
Retrospective Studies
Outcome Assessment (Health Care)

Keywords

  • Anti-Müllerian hormone
  • ART
  • diminished ovarian reserve
  • elevated FSH levels
  • Müllerian inhibiting substance
  • ovarian response

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Random anti-Müllerian hormone (AMH) is a predictor of ovarian response in women with elevated baseline early follicular follicle-stimulating hormone levels. / Buyuk, Erkan; Seifer, David; Younger, Joshua; Grazi, Richard V.; Lieman, Harry.

In: Fertility and Sterility, Vol. 95, No. 7, 06.2011, p. 2369-2372.

Research output: Contribution to journalArticle

Buyuk, Erkan ; Seifer, David ; Younger, Joshua ; Grazi, Richard V. ; Lieman, Harry. / Random anti-Müllerian hormone (AMH) is a predictor of ovarian response in women with elevated baseline early follicular follicle-stimulating hormone levels. In: Fertility and Sterility. 2011 ; Vol. 95, No. 7. pp. 2369-2372.
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abstract = "Objective: To investigate the utility of random anti-M{\"u}llerian hormone (AMH) in assessing ovarian response among women with diminished ovarian reserve (DOR) diagnosed by elevated early follicular-phase FSH levels. Design: Retrospective study. Setting: Academic and academically affiliated assisted reproductive technology (ART) programs. Patient(s): Seventy-three women undergoing ART with elevated early follicular FSH levels. Intervention(s): None. Main Outcome Measure(s): Number of oocytes retrieved during ART cycle, number of day 3 embryos, and cycle cancellation and clinical pregnancy rates. Result(s): Random AMH levels were strongly correlated with the number of oocytes retrieved during an ART cycle among women with elevated FSH (r = 0.55). Women with elevated FSH who had a random serum AMH level of 0.6 ng/mL or higher had twice the number of oocytes retrieved (11 ± 1.3 vs. 5.6 ± 0.6), a greater number of day 3 embryos (5.7 ± 0.9 vs. 3 ± 0.5), and approximately a third of the cycle cancellation rate (14{\%} vs. 41{\%}) compared with women with a random serum AMH below 0.6 ng/mL. The clinical pregnancy rate was also higher among women with a random serum AMH ≥0.6 ng/mL (28{\%} vs. 14{\%}), however, the difference was not statistically significant. Conclusion(s): A random serum AMH level is useful in setting expectations for ART prognosis in women with elevated early follicular-phase serum FSH levels.",
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