Radiotherapy and the tumor microenvironment: Mutual influence and clinical implications

Reid F. Thompson, Amit Maity

Research output: Chapter in Book/Report/Conference proceedingConference contribution

23 Scopus citations

Abstract

Ionizing radiation has been employed in targeted cancer treatments for more than a century because of its cytotoxic effects on cancer cells. However, the responsiveness to radiation and the behavior of tumors in vivo may differ dramatically from observed behaviors of isolated cancer cells in vitro. While not fully understood, these discrepancies are due to a complex constellation of extracellular and intercellular factors that are together termed the tumor microenvironment. Radiation may alter or affect the components of the adjacent tumor microenvironment in significant ways, often with consequences for cancer cells beyond the direct effects of the radiation itself. Moreover, different microenvironmental states, whether induced or at baseline, can modulate or even attenuate the effects of radiation, with consequences for therapeutic efficacy. This chapter describes this bidirectional relationship in detail, exploring the role and clinical implications of the tumor microenvironment with respect to therapeutic irradiation.

Original languageEnglish (US)
Title of host publicationTumor Microenvironment and Cellular Stress
Subtitle of host publicationSignaling, Metabolism, Imaging, and Therapeutic Targets
PublisherSpringer New York LLC
Pages147-165
Number of pages19
ISBN (Print)9781461459149
DOIs
StatePublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume772
ISSN (Print)0065-2598

Keywords

  • Abscopal effect
  • Bystander effect
  • Extracellular matrix
  • Hypoxia
  • Radiation
  • Radiotherapy
  • Tumor microenvironment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Thompson, R. F., & Maity, A. (2014). Radiotherapy and the tumor microenvironment: Mutual influence and clinical implications. In Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging, and Therapeutic Targets (pp. 147-165). (Advances in Experimental Medicine and Biology; Vol. 772). Springer New York LLC. https://doi.org/10.1007/978-1-4614-5915-6_7