TY - JOUR
T1 - Radiopharmaceutical preparation of technetium-99m-labeled galactosyl neoglycoalbumin
AU - Vera, David R.
AU - Stadalnik, Robert C.
AU - Kudo, Masatoshi
AU - Krohn, Kenneth A.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - The principal safety features of an injectable solution are sterility and apyrogenicity. A sterile solution does not contain living organisms; an apyrogenic solution does not contain metabolic products of living organisms or debris of dead organisms which can cause a pyretic response on injection. In humans the pyretic response illicits a sudden onset of chills and fever. The chapter describes a method for the laboratory-scale production of an injectable solution of a radiolabeled neoglycoalbumin. This method is applicable to any radiolabeled macromolecule and is directed toward the academic setting where moderate amounts of injectable material are required for testing “proof-of-principle” or a clinical hypothesis.
AB - The principal safety features of an injectable solution are sterility and apyrogenicity. A sterile solution does not contain living organisms; an apyrogenic solution does not contain metabolic products of living organisms or debris of dead organisms which can cause a pyretic response on injection. In humans the pyretic response illicits a sudden onset of chills and fever. The chapter describes a method for the laboratory-scale production of an injectable solution of a radiolabeled neoglycoalbumin. This method is applicable to any radiolabeled macromolecule and is directed toward the academic setting where moderate amounts of injectable material are required for testing “proof-of-principle” or a clinical hypothesis.
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U2 - 10.1016/S0076-6879(94)47031-6
DO - 10.1016/S0076-6879(94)47031-6
M3 - Article
C2 - 7898368
AN - SCOPUS:0028672656
VL - 247
SP - 402
EP - 409
JO - Methods in Enzymology
JF - Methods in Enzymology
SN - 0076-6879
IS - C
ER -