Abstract
The principal safety features of an injectable solution are sterility and apyrogenicity. A sterile solution does not contain living organisms; an apyrogenic solution does not contain metabolic products of living organisms or debris of dead organisms which can cause a pyretic response on injection. In humans the pyretic response illicits a sudden onset of chills and fever. The chapter describes a method for the laboratory-scale production of an injectable solution of a radiolabeled neoglycoalbumin. This method is applicable to any radiolabeled macromolecule and is directed toward the academic setting where moderate amounts of injectable material are required for testing “proof-of-principle” or a clinical hypothesis.
Original language | English (US) |
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Pages (from-to) | 402-409 |
Number of pages | 8 |
Journal | Methods in Enzymology |
Volume | 247 |
Issue number | C |
DOIs | |
State | Published - Jan 1 1994 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology