Radiolabeled hypoxic cell sensitizers: Tracers for assessment of ischemia

Carla J. Mathias, Michael J. Welch, Michael R. Kilbourn, Paul A. Jerabek, Timothy B. Patrick, Marcus E. Raichle, Kenneth Krohn, Janet S. Rasey, Dennis W. Shaw

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Hypoxic, non-functional, but viable, tissue may exist in heart and brain following an arterial occlusion. Identification of such tissue in vivo is crucial to the development of effective treatment strategies. It has been suggested that certain compounds capable of sensitizing hypoxic tumor cells to killing by x-rays (i.e., misonidazole) might serve as in vivo markers of hypoxic tissue in ischemic myocardium or brain if properly radiolabeled. To this end we have radiolabeled two fluorinated analogs of nitroimidazole based hypoxic cell sensitizers with the 110 minute half-lived positron-emitting fluorine-18. The ability of these tracers to quantitate the presence of hypoxic tissue has been studied in a gerbil stroke model. The in vivo uptake of one of these tracers [F-18]-fluoronormethyoxymisonidazole is dependent on the extent of tissue hypoxia, and thus, appears to have potential as a diagnostic indicator of non-functional but viable tissue when the tracer is used in conjunction with positron emission tomography.

Original languageEnglish (US)
Pages (from-to)199-206
Number of pages8
JournalLife Sciences
Volume41
Issue number2
DOIs
Publication statusPublished - Jul 13 1987
Externally publishedYes

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ASJC Scopus subject areas

  • Pharmacology

Cite this

Mathias, C. J., Welch, M. J., Kilbourn, M. R., Jerabek, P. A., Patrick, T. B., Raichle, M. E., ... Shaw, D. W. (1987). Radiolabeled hypoxic cell sensitizers: Tracers for assessment of ischemia. Life Sciences, 41(2), 199-206. https://doi.org/10.1016/0024-3205(87)90494-2