Radiation-induced painful neurogenic hypertrophy treated with botulinum toxin A

Alexandra Filippakis, Doreen T. Ho, Juan E. Small, Kirstin M. Small, Erik Ensrud

Research output: Contribution to journalArticle

Abstract

Painful neurogenic hypertrophy is a rare complication of radiation therapy. We report a 27-year-old woman with a history of adenoid cystic carcinoma of the submandibular gland presented with painful twitching of her left shoulder. Electrodiagnostic studies were consistent with a diagnosis of radiation-induced spinal accessory nerve hyperactivity. The patient failed conventional medical therapy. She was treated with an injection of botulinum toxin A, and within 1 month experienced significant relief of symptoms. We thus conclude that Botulinum toxin is a therapeutic option for the pain associated with radiation-induced peripheral nerve hyperactivity.

Original languageEnglish (US)
Pages (from-to)135-137
Number of pages3
JournalJournal of Clinical Neuromuscular Disease
Volume19
Issue number3
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Fingerprint

Type A Botulinum Toxins
Hypertrophy
Accessory Nerve
Radiation
Adenoid Cystic Carcinoma
Botulinum Toxins
Submandibular Gland
Peripheral Nerves
Radiotherapy
Pain
Injections
Therapeutics

Keywords

  • Botulinum toxin
  • Neurogenic hypertrophy
  • Radiation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Radiation-induced painful neurogenic hypertrophy treated with botulinum toxin A. / Filippakis, Alexandra; Ho, Doreen T.; Small, Juan E.; Small, Kirstin M.; Ensrud, Erik.

In: Journal of Clinical Neuromuscular Disease, Vol. 19, No. 3, 01.01.2018, p. 135-137.

Research output: Contribution to journalArticle

Filippakis, Alexandra ; Ho, Doreen T. ; Small, Juan E. ; Small, Kirstin M. ; Ensrud, Erik. / Radiation-induced painful neurogenic hypertrophy treated with botulinum toxin A. In: Journal of Clinical Neuromuscular Disease. 2018 ; Vol. 19, No. 3. pp. 135-137.
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