Radiation dose calculation of Tc-99m HIDA in health and disease

Paul Brown, G. T. Krishnamurthy, V. V R Bobba, E. Kingston

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Radiation dose from Tc-99m HIDA has been calculated for normal subjects and for patients with various hepatobiliary diseases classified into four groups based on serum bilirubin level. The calculation was performed on biokinetic radioactivity data from blood, urine, liver, gallbladder, and intestines, using a biological approach that included a catenary model of the digestive organs. For normal subjects the critical organs were the gallbladder and the upper and lower large intestine, with doses of 910, 300, 200 mrad/mCi, respectively. The bone marrow, ovaries, and testes received 24, 62, and 4 mrad/mCi. For Group 4 patients with severe hepatobiliary disease (bilirubin>10 mg/dl), the critical organs were the kidney, urinary bladder, and gallbladder, with doses of 130, 110, and 100 mrad/mCi. The bone marrow, ovaries, and testes received 9, 13, and 5 mrad/mCi. Thus the critical organs and overall radiation doses to organs change between health and disease.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalJournal of Nuclear Medicine
Volume22
Issue number2
StatePublished - 1981

Fingerprint

Gallbladder
Radiation
Bilirubin
Testis
Ovary
Health
Bone Marrow
Large Intestine
Radioactivity
Intestines
Urinary Bladder
Urine
Kidney
Liver
Serum
lidofenin

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Brown, P., Krishnamurthy, G. T., Bobba, V. V. R., & Kingston, E. (1981). Radiation dose calculation of Tc-99m HIDA in health and disease. Journal of Nuclear Medicine, 22(2), 177-183.

Radiation dose calculation of Tc-99m HIDA in health and disease. / Brown, Paul; Krishnamurthy, G. T.; Bobba, V. V R; Kingston, E.

In: Journal of Nuclear Medicine, Vol. 22, No. 2, 1981, p. 177-183.

Research output: Contribution to journalArticle

Brown, P, Krishnamurthy, GT, Bobba, VVR & Kingston, E 1981, 'Radiation dose calculation of Tc-99m HIDA in health and disease', Journal of Nuclear Medicine, vol. 22, no. 2, pp. 177-183.
Brown P, Krishnamurthy GT, Bobba VVR, Kingston E. Radiation dose calculation of Tc-99m HIDA in health and disease. Journal of Nuclear Medicine. 1981;22(2):177-183.
Brown, Paul ; Krishnamurthy, G. T. ; Bobba, V. V R ; Kingston, E. / Radiation dose calculation of Tc-99m HIDA in health and disease. In: Journal of Nuclear Medicine. 1981 ; Vol. 22, No. 2. pp. 177-183.
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