Rabbit plasma fibronectin levels associated with staphylococcus aureus enterotoxin b: An acute-phase reaction

Roger E. Bawdon, Lowell E. Davis, Bertis B. Little

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Variation in fibronectin (Fn) levels and white blood cell counts (WBC) following staphylococcal enterotoxin B (SEB) or SEB + cryoprecipitate containing Fn challenge was studied in New Zealand white rabbits. Increased plasma Fn levels were observed 2 h after the intravenous injection of SEB and peaked at 48-72 h (from a mean level 194.6 ± 4.5 µg/ml prechallenge Fn level to a 72-hour postchallenge mean level of 407.9 ± 25.4 µg/ml). Fn levels then decreased over the succeeding 5 days to approximately prechallenge levels. The total WBC count decreased by 88% within 2 h after the SEB injection. A slow increase in circulatory WBC was observed over the next 24 h. SEB caused an increase in plasma Fn levels and decreased WBC counts with lymphopenia that was followed by a normal lymphocyte count within 5 days. These data suggest that an acute-phase reaction was induced by interleukin-1. Fn prophylaxis provided no change in clinical signs when given at the time of SEB injection.

Original languageEnglish (US)
Pages (from-to)191-194
Number of pages4
JournalGynecologic and Obstetric Investigation
Volume28
Issue number4
DOIs
StatePublished - Jan 1 1989

Keywords

  • Acute-phase reaction
  • Enterotoxin B
  • Fibronectin

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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