Quinolinic Acid

Jodi McBride, S. Ramaswamy, J. H. Kordower

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Quinolinic acid (QA) is a metabolite of tryptophan that binds to N-methyl-d-aspartate (NMDA) receptors in the central nervous system. Overstimulation of these receptors leads to excitotoxicity and cell death of neurons harboring these receptors. QA has been widely used in animals to model particular neurodegenerative disorders, especially Huntington's disease.

    Original languageEnglish (US)
    Title of host publicationEncyclopedia of Movement Disorders
    PublisherElsevier Inc.
    Pages1-3
    Number of pages3
    ISBN (Electronic)9780123741059
    ISBN (Print)9780123741011
    DOIs
    StatePublished - Jan 1 2010

    Keywords

    • Amino acid
    • Animal model
    • Brain
    • Excitotoxicity
    • Glutamate agonist
    • Huntington's disease
    • Kynurenine
    • Neurodegeneration
    • Neurotoxin
    • NMDA receptor
    • Striatum
    • Tryptophan

    ASJC Scopus subject areas

    • Medicine(all)
    • Neuroscience(all)

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  • Cite this

    McBride, J., Ramaswamy, S., & Kordower, J. H. (2010). Quinolinic Acid. In Encyclopedia of Movement Disorders (pp. 1-3). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374105-9.00418-4