Quinolinic Acid

J. L. McBride; S. Ramaswamy; J. H. Kordower

doi:10.1016/B978-0-12-374105-9.00418-4

Quinolinic Acid

J. L. McBride, S. Ramaswamy, J. H. Kordower

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Quinolinic acid (QA) is a metabolite of tryptophan that binds to N-methyl-d-aspartate (NMDA) receptors in the central nervous system. Overstimulation of these receptors leads to excitotoxicity and cell death of neurons harboring these receptors. QA has been widely used in animals to model particular neurodegenerative disorders, especially Huntington's disease.

Original language	English (US)
Title of host publication	Encyclopedia of Movement Disorders
Publisher	Elsevier Inc.
Pages	1-3
Number of pages	3
ISBN (Electronic)	9780123741059
ISBN (Print)	9780123741011
DOIs	https://doi.org/10.1016/B978-0-12-374105-9.00418-4
State	Published - Jan 1 2010

Keywords

Amino acid
Animal model
Brain
Excitotoxicity
Glutamate agonist
Huntington's disease
Kynurenine
Neurodegeneration
Neurotoxin
NMDA receptor
Striatum
Tryptophan

ASJC Scopus subject areas

Medicine(all)
Neuroscience(all)

Access to Document

10.1016/B978-0-12-374105-9.00418-4

Cite this

@inbook{082c1c25b9864b638b12cefdbb839dd0,

title = "Quinolinic Acid",

abstract = "Quinolinic acid (QA) is a metabolite of tryptophan that binds to N-methyl-d-aspartate (NMDA) receptors in the central nervous system. Overstimulation of these receptors leads to excitotoxicity and cell death of neurons harboring these receptors. QA has been widely used in animals to model particular neurodegenerative disorders, especially Huntington's disease.",

keywords = "Amino acid, Animal model, Brain, Excitotoxicity, Glutamate agonist, Huntington's disease, Kynurenine, Neurodegeneration, Neurotoxin, NMDA receptor, Striatum, Tryptophan",

author = "McBride, {J. L.} and S. Ramaswamy and Kordower, {J. H.}",

year = "2010",

month = jan,

day = "1",

doi = "10.1016/B978-0-12-374105-9.00418-4",

language = "English (US)",

isbn = "9780123741011",

pages = "1--3",

booktitle = "Encyclopedia of Movement Disorders",

publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Quinolinic Acid

AU - McBride, J. L.

AU - Ramaswamy, S.

AU - Kordower, J. H.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Quinolinic acid (QA) is a metabolite of tryptophan that binds to N-methyl-d-aspartate (NMDA) receptors in the central nervous system. Overstimulation of these receptors leads to excitotoxicity and cell death of neurons harboring these receptors. QA has been widely used in animals to model particular neurodegenerative disorders, especially Huntington's disease.

AB - Quinolinic acid (QA) is a metabolite of tryptophan that binds to N-methyl-d-aspartate (NMDA) receptors in the central nervous system. Overstimulation of these receptors leads to excitotoxicity and cell death of neurons harboring these receptors. QA has been widely used in animals to model particular neurodegenerative disorders, especially Huntington's disease.

KW - Amino acid

KW - Animal model

KW - Brain

KW - Excitotoxicity

KW - Glutamate agonist

KW - Huntington's disease

KW - Kynurenine

KW - Neurodegeneration

KW - Neurotoxin

KW - NMDA receptor

KW - Striatum

KW - Tryptophan

UR - http://www.scopus.com/inward/record.url?scp=85069811331&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85069811331&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-374105-9.00418-4

DO - 10.1016/B978-0-12-374105-9.00418-4

M3 - Chapter

AN - SCOPUS:85069811331

SN - 9780123741011

SP - 1

EP - 3

BT - Encyclopedia of Movement Disorders

PB - Elsevier Inc.

ER -

Quinolinic Acid

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this