Quantum dots monitor TrkA receptor dynamics in the interior of neural PC12 Cells

Sujata Sundara Rajan, Tania Q. Vu

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Can quantum dots (QDs) serve as physiologically relevant receptor probes in the interior of cells? We directly visualize endocytosis, redistribution, and shuttling of QD bound-TrkA receptors to PC12 neural processes and far-reaching growth cone tips. Internalized QDs are contained in microtubule-associated vesicles and possess transport properties that reflect TrkA receptor dynamics. This opens up new possibilities for the development of QD platforms as molecular tools to image biochemical signaling and transport cargo in the cell interior.

Original languageEnglish (US)
Pages (from-to)2049-2059
Number of pages11
JournalNano Letters
Volume6
Issue number9
DOIs
StatePublished - Sep 1 2006

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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