Quantitative trait locus gene mapping: A new method for locating alcohol response genes

John C. Crabbe

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Alcoholism is a multigenic trait with important non-genetic determinants. Studies with genetic animal models of susceptibility to several of alcohol's effects suggest that several genes contributing modest effects on susceptibility (Quantitative Trait Loci, or QTLs) are important. A new technique of QTL gene mapping has allowed the identification of the location in mouse genome of several such QTLs. The method is described, and the locations of QTLs affecting the acute alcohol withdrawal reaction are described as an example of the method. Verification of these QTLs in ancillary studies is described and the strengths, limitations, and future directions to be pursued are discussed. QTL mapping is a promising method for identifying genes in rodents with the hope of directly extrapolating the results to the human genome.

Original languageEnglish (US)
Pages (from-to)229-235
Number of pages7
JournalAddiction Biology
Issue number3
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Psychiatry and Mental health


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