Quantitative trait loci (QTL) applications to substances of abuse

Physical dependence studies with nitrous oxide and ethanol in BXD mice

John Belknap, P. Metten, M. L. Helms, L. A. O'Toole, S. Angeli-Gade, John Jr Crabbe, Tamara Phillips

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Recombinant inbred (RI) mouse strains were developed primarily as a tool to detect and provisionally map major gene loci-those with effects large enough to cause a bimodal distribution in the trait of interest. This implied that progress toward gene mapping was possible only for gene loci accounting for at least half of the genetic variance. More recently, QTL (quantitative trait loci) approaches have been advanced that do not require bimodal distributions and are thus applicable to a much wider range of phenotypes. They offer the prospect of meaningful progress toward detecting and mapping minor as well as major gene loci affecting any trait of interest, provided there is a significant degree of genetic determination among the RI strains. This paper presents a review of RI gene mapping efforts concerning phenotypes related to drug abuse and presents new data for studies now in progress for nitrous oxide and acute ethanol withdrawal intensity. These two studies exemplify several strengths and limitations of the RI QTL approach.

Original languageEnglish (US)
Pages (from-to)213-222
Number of pages10
JournalBehavior Genetics
Volume23
Issue number2
DOIs
StatePublished - Mar 1993

Fingerprint

substance abuse
Quantitative Trait Loci
Nitrous Oxide
nitrous oxide
Substance-Related Disorders
ethanol
quantitative trait loci
Ethanol
Chromosome Mapping
major genes
loci
chromosome mapping
gene
mice
Genes
Phenotype
phenotype
drug abuse
Inbred Strains Mice
genetic variance

Keywords

  • BXD
  • C57BL/6
  • chromosome mapping
  • DBA/2
  • drug abuse
  • ethanol
  • mouse
  • nitrous oxide
  • Quantitative trait loci (QTL)
  • recombinant inbred strains
  • withdrawal syndromes

ASJC Scopus subject areas

  • Psychology(all)
  • Behavioral Neuroscience
  • Genetics(clinical)
  • Genetics

Cite this

Quantitative trait loci (QTL) applications to substances of abuse : Physical dependence studies with nitrous oxide and ethanol in BXD mice. / Belknap, John; Metten, P.; Helms, M. L.; O'Toole, L. A.; Angeli-Gade, S.; Crabbe, John Jr; Phillips, Tamara.

In: Behavior Genetics, Vol. 23, No. 2, 03.1993, p. 213-222.

Research output: Contribution to journalArticle

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