Quantitative real-time cross-sectional echocardiography in the developing normal human fetus and newborn

David Sahn, L. W. Lange, H. D. Allen, S. J. Goldberg, C. Anderson, H. Giles, K. Haber

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

New high-resolution real-time ultrasound cross-sectional imaging systems have enabled us to demonstrate detailed fetal cardiac anatomy in the second half of pregnancy. We studied normal fetal cardiac development quantitatively by echocardiography in the second half of pregnancy in 69 normal pregnancies of healthy mothers. Eighteen of the fetuses were followed serially before birth. The estimated gestational ages were 20-41 weeks (mean 31.7±0.5 weeks [SEM]) of pregnancy. Calculated fetal weights were 500-3100 g (mean 1590±83 g). Fetuses were reexamined within 36 hours after birth by real-time cross-sectional echocardiography to provide comparative data for the assessment of circulatory changes that take place at birth. Measurements of the right and left ventricles at the atrioventricular valve level were taken from four-chamber plane images of the heart before and after birth, and measurements of the aorta and pulmonary artery were taken in the short-axis view. All measurements were taken at end-diastole and were related to calculated fetal or actual newborn body weight. Statistical analysis for fetal cardiac dimension, right (RV) and left ventricular (LV) dimension and great artery size showed good correlation to calculated fetal weight, and growth curves for fetal cardiac structures were derived. Physiologic changes in the circulation at birth affected RV size considerably compared with measurements before birth. The RV/LV dimensional ratio was 1.18±0.01 before birth and decreased to 0.99±0.03 (p

Original languageEnglish (US)
Pages (from-to)588-597
Number of pages10
JournalCirculation
Volume62
Issue number3
StatePublished - 1980
Externally publishedYes

Fingerprint

Echocardiography
Fetus
Parturition
Pregnancy
Fetal Weight
Fetal Development
Heart Ventricles
Diastole
Pulmonary Artery
Gestational Age
Aorta
Anatomy
Arteries
Body Weight

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Sahn, D., Lange, L. W., Allen, H. D., Goldberg, S. J., Anderson, C., Giles, H., & Haber, K. (1980). Quantitative real-time cross-sectional echocardiography in the developing normal human fetus and newborn. Circulation, 62(3), 588-597.

Quantitative real-time cross-sectional echocardiography in the developing normal human fetus and newborn. / Sahn, David; Lange, L. W.; Allen, H. D.; Goldberg, S. J.; Anderson, C.; Giles, H.; Haber, K.

In: Circulation, Vol. 62, No. 3, 1980, p. 588-597.

Research output: Contribution to journalArticle

Sahn, D, Lange, LW, Allen, HD, Goldberg, SJ, Anderson, C, Giles, H & Haber, K 1980, 'Quantitative real-time cross-sectional echocardiography in the developing normal human fetus and newborn', Circulation, vol. 62, no. 3, pp. 588-597.
Sahn D, Lange LW, Allen HD, Goldberg SJ, Anderson C, Giles H et al. Quantitative real-time cross-sectional echocardiography in the developing normal human fetus and newborn. Circulation. 1980;62(3):588-597.
Sahn, David ; Lange, L. W. ; Allen, H. D. ; Goldberg, S. J. ; Anderson, C. ; Giles, H. ; Haber, K. / Quantitative real-time cross-sectional echocardiography in the developing normal human fetus and newborn. In: Circulation. 1980 ; Vol. 62, No. 3. pp. 588-597.
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