Quantitative OCT angiography of optic nerve head blood flow

Jia Yali, John Morrison, Jason Tokayer, Ou Tan, Lorinna Lombardi, Bernhard Baumann, Chen D. Lu, Woojhon Choi, James G. Fujimoto, David Huang

Research output: Contribution to journalArticle

236 Citations (Scopus)

Abstract

Optic nerve head (ONH) blood flow may be associated with glaucoma development. A reliable method to quantify ONH blood flow could provide insight into the vascular component of glaucoma pathophysiology. Using ultrahigh-speed optical coherence tomography (OCT), we developed a new 3D angiography algorithm called splitspectrum amplitude-decorrelation angiography (SSADA) for imaging ONH microcirculation. In this study, a method to quantify SSADA results was developed and used to detect ONH perfusion changes in early glaucoma. En face maximum projection was used to obtain 2D disc angiograms, from which the average decorrelation values (flow index) and the percentage area occupied by vessels (vessel density) were computed from the optic disc and a selected region within it. Preperimetric glaucoma patients had significant reductions of ONH perfusion compared to normals. This pilot study indicates OCT angiography can detect the abnormalities of ONH perfusion and has the potential to reveal the ONH blood flow mechanism related to glaucoma.

Original languageEnglish (US)
Pages (from-to)3127-3137
Number of pages11
JournalBiomedical Optics Express
Volume3
Issue number12
DOIs
StatePublished - Dec 1 2012

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angiography
Optic Disk
Optical Coherence Tomography
nerves
blood flow
glaucoma
Angiography
tomography
optics
Glaucoma
Perfusion
vessels
abnormalities
Microcirculation
Blood Vessels
projection

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

Cite this

Quantitative OCT angiography of optic nerve head blood flow. / Yali, Jia; Morrison, John; Tokayer, Jason; Tan, Ou; Lombardi, Lorinna; Baumann, Bernhard; Lu, Chen D.; Choi, Woojhon; Fujimoto, James G.; Huang, David.

In: Biomedical Optics Express, Vol. 3, No. 12, 01.12.2012, p. 3127-3137.

Research output: Contribution to journalArticle

Yali, Jia ; Morrison, John ; Tokayer, Jason ; Tan, Ou ; Lombardi, Lorinna ; Baumann, Bernhard ; Lu, Chen D. ; Choi, Woojhon ; Fujimoto, James G. ; Huang, David. / Quantitative OCT angiography of optic nerve head blood flow. In: Biomedical Optics Express. 2012 ; Vol. 3, No. 12. pp. 3127-3137.
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