@inbook{c5edb52d01c7445399f7fe9ca5279733,
title = "Quantitative Drug Target Imaging Using Paired-Agent Principles",
abstract = "Molecular imaging is often proposed to provide a direct measure of drug targets; however, physiological effects of imaging-agent delivery rates and nonspecific retention can obfuscate the relationship between imaging-agent distribution and the biological distribution of the targeted biomolecule. Coadministration of a suitable control imaging-agent (“nontargeted” version of the targeted agent) simultaneously with a targeted imaging-agent offers a promising solution to account for the nonspecific effects in single-agent molecular imaging and can provide quantitative measures of drug target distribution and availability. This chapter provides an overview of these “paired-agent” molecular imaging protocols with thorough descriptions of how to extract estimates of drug target concentration from paired-agent data under a number of conditions: topical and systemic delivery, and imaging of intravascular, extracellular, and intracellular drug targets.",
keywords = "Cancer, Drug target, Kinetic modeling, Molecular imaging, Paired-agent",
author = "Tichauer, {Kenneth M.} and Negar Sadeghipour and Wang, {Yu Winston} and Gibbs, {Summer L.} and Liu, {Jonathan T.C.} and Samkoe, {Kimberley S.}",
note = "Publisher Copyright: {\textcopyright} 2021, Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2021",
doi = "10.1007/978-1-0716-1250-7_13",
language = "English (US)",
series = "Methods in Pharmacology and Toxicology",
publisher = "Humana Press Inc.",
pages = "275--304",
booktitle = "Methods in Pharmacology and Toxicology",
}