Quantitative Drug Target Imaging Using Paired-Agent Principles

Kenneth M. Tichauer, Negar Sadeghipour, Yu Winston Wang, Summer L. Gibbs, Jonathan T.C. Liu, Kimberley S. Samkoe

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Molecular imaging is often proposed to provide a direct measure of drug targets; however, physiological effects of imaging-agent delivery rates and nonspecific retention can obfuscate the relationship between imaging-agent distribution and the biological distribution of the targeted biomolecule. Coadministration of a suitable control imaging-agent (“nontargeted” version of the targeted agent) simultaneously with a targeted imaging-agent offers a promising solution to account for the nonspecific effects in single-agent molecular imaging and can provide quantitative measures of drug target distribution and availability. This chapter provides an overview of these “paired-agent” molecular imaging protocols with thorough descriptions of how to extract estimates of drug target concentration from paired-agent data under a number of conditions: topical and systemic delivery, and imaging of intravascular, extracellular, and intracellular drug targets.

Original languageEnglish (US)
Title of host publicationMethods in Pharmacology and Toxicology
PublisherHumana Press Inc.
Pages275-304
Number of pages30
DOIs
StatePublished - 2021

Publication series

NameMethods in Pharmacology and Toxicology
ISSN (Print)1557-2153
ISSN (Electronic)1940-6053

Keywords

  • Cancer
  • Drug target
  • Kinetic modeling
  • Molecular imaging
  • Paired-agent

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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