TY - JOUR
T1 - Quantitative biliary dynamics
T2 - introduction of a new noninvasive scintigraphic technique
AU - Krishnamurthy, G. T.
AU - Bobba, V. R.
AU - McConnell, D.
AU - Turner, F.
AU - Mesgarzadeh, M.
AU - Kingston, E.
PY - 1983
Y1 - 1983
N2 - We used a Tc-99m-labeled hepatobiliary agent to measure the partition of hepatic bile between gallbladder and intestine in sixteen normal patients and nine patients with cholelithiasis. In normal subjects, the fractions of the hepatic bile that flow into the gallbladder and the small intestine were widely variable, with mean values of 69 ± 7% (s.e.) and 31 ±7% respectively. Bile reflux into the common hepatic duct was rare, occurring during the first 2/3 of the gallblader ejection period and only when the ejection fraction was greater than 59%. The gallbladder's mean latent period, ejection period, ejection fraction, and ejection rate were 2 ± 1 min, 11 ± 1min, 59 ±4%, and 5.9%/min respectively. In patients with cholelithiasis, the fraction of hepatic bile flowing into the gallbladder was normal, but the ejection fraction was significantly reduced (p<0.005). For an equivalent dose of cholecystokinin, the gallbladder in cholelithiasis is less responsive than in normal subjects.
AB - We used a Tc-99m-labeled hepatobiliary agent to measure the partition of hepatic bile between gallbladder and intestine in sixteen normal patients and nine patients with cholelithiasis. In normal subjects, the fractions of the hepatic bile that flow into the gallbladder and the small intestine were widely variable, with mean values of 69 ± 7% (s.e.) and 31 ±7% respectively. Bile reflux into the common hepatic duct was rare, occurring during the first 2/3 of the gallblader ejection period and only when the ejection fraction was greater than 59%. The gallbladder's mean latent period, ejection period, ejection fraction, and ejection rate were 2 ± 1 min, 11 ± 1min, 59 ±4%, and 5.9%/min respectively. In patients with cholelithiasis, the fraction of hepatic bile flowing into the gallbladder was normal, but the ejection fraction was significantly reduced (p<0.005). For an equivalent dose of cholecystokinin, the gallbladder in cholelithiasis is less responsive than in normal subjects.
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M3 - Article
C2 - 6827367
AN - SCOPUS:0020581972
SN - 0161-5505
VL - 24
SP - 217
EP - 223
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
IS - 3
ER -